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相关概念视频

Cis-regulatory Sequences02:02

Cis-regulatory Sequences

11.6K
Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
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Cis-regulatory Sequences02:02

Cis-regulatory Sequences

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What is Gene Expression?01:42

What is Gene Expression?

194.7K
Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
194.7K
Cell Specific Gene Expression01:58

Cell Specific Gene Expression

16.3K
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
16.3K
Combinatorial Gene Control02:33

Combinatorial Gene Control

9.5K
Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
9.5K
PD Controller: Design01:26

PD Controller: Design

630
In automotive engineering, car suspension systems often employ Proportional Derivative (PD) controllers to enhance performance. PD controllers are utilized to adjust the damping force in response to road conditions. A controller, acting as an amplifier with a constant gain, demonstrates proportional control, with output directly mirroring input.
Designing a continuous-data controller requires selecting and linking components like adders and integrators, which are fundamental in Proportional,...
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Updated: Jan 21, 2026

Quantifying the Activity of cis-Regulatory Elements in the Mouse Retina by Explant Electroporation
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Quantifying the Activity of cis-Regulatory Elements in the Mouse Retina by Explant Electroporation

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使用人工智能设计的Cis调节元件控制基因表达.

Yan Xia1, Yi-Xin Huo2

  • 1Department of Gastroenterology, Aerospace Center Hospital, College of Life Science, Beijing Institute of Technology, No. 5 South Zhongguancun Street, Haidian District, Beijing 100081, China; Zhongguancun Academy, Beijing 100094, China.

Biotechnology advances
|January 19, 2026
PubMed
概括
此摘要是机器生成的。

人工智能 (AI) 正在彻底改变用于基因表达控制的 cis 调节元件 (CREs) 的设计. 虽然人工智能看起来有前途,但对于先进的合成生物学来说,数据限制和可解释性等挑战需要解决.

关键词:
DNA基础模型的模型.深度学习是一种深度学习.增强器 增强器 增强器生成型模型是一种生成型模型.活动主办人 活动主办人监管要素 监管要素 监管要素

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Prediction and Validation of Gene Regulatory Elements Activated During Retinoic Acid Induced Embryonic Stem Cell Differentiation
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Using an Automated Cell Counter to Simplify Gene Expression Studies: siRNA Knockdown of IL-4 Dependent Gene Expression in Namalwa Cells
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Using an Automated Cell Counter to Simplify Gene Expression Studies: siRNA Knockdown of IL-4 Dependent Gene Expression in Namalwa Cells

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相关实验视频

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Quantifying the Activity of cis-Regulatory Elements in the Mouse Retina by Explant Electroporation

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Prediction and Validation of Gene Regulatory Elements Activated During Retinoic Acid Induced Embryonic Stem Cell Differentiation
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科学领域:

  • 基因组学就是基因组学.
  • 合成生物学 合成生物学
  • 计算生物学 计算生物学

背景情况:

  • 基因调节元件 (CREs) 对基因表达至关重要,但传统的设计方法效率低下.
  • 深度学习的进步正在提高CRE预测,并使合成CRE设计成为可能.

研究的目的:

  • 审查人工智能对CRE设计和预测的影响.
  • 讨论人工智能驱动的CRE工程中的当前挑战和未来方向.

主要方法:

  • 审查深度学习模型,包括专用设计模型和DNA基础模型.
  • 对人工智能与高通量实验数据集成的分析.
  • 检查新兴的人工智能技术,如多式模式建模和强化学习.

主要成果:

  • 人工智能提高了预测准确度,并为设计合成CREs (如促进剂和增强剂) 提供了策略.
  • 人工智能模型显示,在生成复杂的监管架构方面取得了进展.
  • 目前的人工智能方法面临的挑战包括数据稀缺,预测-实验差距和有限的解释性.

结论:

  • 人工智能具有系统和有针对性的合成CRE设计的巨大潜力.
  • 未来的方向包括解决数据质量问题,提高模型解释性,探索多式联络和强化学习方法.
  • 克服当前的局限性是充分实现AI在监管要素工程方面的能力的关键.