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吸烟和心脏代谢和精神疾病的并发症轨迹:一个多州模型

Chengcheng Zhang¹, Yang Zhang², Zhen Ling³

¹Department of Epidemiology and Biostatistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China; Department of Social Medicine and Health Management, Xiangya School of Public Health, Central South University, Changsha, China.

General hospital psychiatry

|January 19, 2026

概括

目前的吸烟显著恶化心脏代谢和精神疾病并发症,增加死亡风险. 然而,戒烟可以大大减轻这些风险,并提高预期寿命.

科学领域:

公共卫生公共卫生
流行病学流行病学
心脏病学心脏病学

背景情况:

心脏代谢性疾病 (CMD) 和精神疾病 (MD) 具有高度的并发症,导致全球疾病负担显著增加.
吸烟是CMD和MD的已知风险因素,但其对它们联合进展的具体影响尚不清楚.

研究的目的:

调查吸烟状态对心脏代谢和精神疾病并发症的轨迹的影响.
量化戒烟对疾病进展和预期寿命的影响.

主要方法:

对355,488名英国生物库参与者进行了前性队列研究.
采用多状态模型来分析CMD,MD,并发症和死亡之间的过渡,基于吸烟状态 (从未,以前,当前).
事件CMD和MD通过链接健康记录,自我报告和死亡登记册来确定.

主要成果:

与以前或从未吸烟者相比,目前吸烟者过渡到CMD,MD和共患病的可能性更高.
当前吸烟增加了从多发性疾病转变为心血管疾病的风险 (HR=1.63),心血管疾病转变为多发性疾病的风险 (HR=1.45),并导致死亡的并发性疾病 (HR=2.43).
戒烟减轻了这些风险 (HRs 0.45-0.93),并减少了与并发症相关的预期寿命减少 (目前的吸烟者: -6.88年;以前的吸烟者: -0.84年).

结论:

目前的吸烟对伴随性疾病的发展产生更深远的影响,而不是单个CMD或MD的初始发病.
虽然活跃吸烟会增加死亡风险,但戒烟有效地减少了伴随性CMD和MD患者的预期寿命.

关键词:

焦虑焦虑是一种焦虑.心脏代谢性疾病心脏代谢性疾病伴随性疾病伴随性疾病抑郁症抑郁症抑郁症吸烟吸烟吸烟吸烟

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