在青少年接种COVID-19疫苗后,月经周期变化的炎症机制发生变化
Ariel B Handy1, Boyu Ren1, Laura C Seidman2
1McLean Hospital, Belmont, MA, United States; Harvard Medical School, Boston, MA, United States.
Vaccine
|January 19, 2026
概括
接种COVID-19疫苗可以缩短青少年女孩的月经周期. 这种效应与疫苗接种后炎症标志物介质素-1β (IL-1β) 的水平增加有关,这会影响疫苗接种周期的长度.
科学领域:
- 生殖免疫学 生殖免疫学
- 青少年健康 青少年健康
- 疫苗免疫学 疫苗免疫学
背景情况:
- COVID-19疫苗接种后的月经周期变化已被记录,但机制尚不清楚.
- 炎症是疫苗相关月经变化的假设但未被证明的因素.
研究的目的:
- 在青少年女孩接种COVID-19增剂疫苗后,调查卵巢激素,炎症和月经周期变化之间的联系.
- 探索炎症标志物和激素水平在与疫苗有关的月经周期变化的作用.
主要方法:
- 唾液样本和自报的数据从47名青少年女孩 (13-20岁) 收集,分别来自5个月经周期点.
- 对炎症标志物 (IL-1β,IL-6,TNF-α) 和卵巢激素 (雌激素,孕激素) 的唾液检测.
主要成果:
- 疫苗接种后24小时内白蛋白-1β (IL-1β) 水平升高与更短的月经周期长度相关.
- 没有发现卵巢激素或其他炎症标志物与月经周期变化之间有显著的关联.
- 基于抗高峰IgG水平的独特免疫反应概况与月经周期变化没有显著的相关性.
结论:
- 促炎性细胞因子IL-1β是缩短青少年COVID-19疫苗接种后月经周期的关键因素.
- 疫苗诱导的炎症影响青少年的月经周期调节,可能是由于不成熟的下丘脑-垂体-卵巢 (HPO) 轴.
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