用芯片实现的时间干扰刺激器用于非侵入性神经调节
Yun-Yu Li1, Nan-Hui Huang1, Ming-Dou Ker1
1Institute of Electronics, National Yang Ming Chiao Tung University, 1001 University Road, Institute of Electronics, National Yang Ming Chiao Tung University, TAIWAN, Hsinchu, Taiwan, 300, TAIWAN.
Journal of neural engineering
|January 19, 2026
概括
一个新的微型芯片可以实现便携式时间干扰刺激 (TIS),用于非侵入性神经调节. 这种可穿戴的TIS系统在动物研究中成功引起神经反应,为临床应用铺平了道路.
科学领域:
- 生物医学工程 生物医学工程
- 神经科学是一个神经科学.
- 电气工程 电气工程
背景情况:
- 时间干扰刺激 (TIS) 是一个有前途的非侵入性神经调节技术.
- 现有的TIS系统依赖于重的桌面仪器,限制了可移植性.
- 之前没有报道过用于TIS的专用芯片系统 (SoC).
研究的目的:
- 设计和制造一个小型的,便携式的TIS芯片.
- 为了使时间干扰刺激的可穿戴应用.
- 为了弥补专用TIS硬件的缺口.
主要方法:
- 设计和制造了一种双通道时间干扰刺激器,使用0.18微米CMOS BCD工艺.
- 该TIS芯片的面积为2.66mm2,并产生高达±5V的输出信号.
- 使用多个载波和节拍频率,提供九种不同的操作模式.
主要成果:
- 制造的芯片成功地产生了精确可靠的暂时干扰信号.
- 在活体动物实验中,证明了芯片在诱导猪深部大脑神经反应方面的有效性.
- 与传统的TIS仪器相比,系统芯片设计显著提高了可移植性.
结论:
- 一个完全集成的芯片取代了重的外部TIS刺激器.
- 开发的TIS芯片增强了未来可穿戴临床应用的便携性.
- 这一进步支持下一代非侵入性神经调节装置的开发.
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