用HiGee强化臭氧化,增强水传播抗生素耐药细菌的无活化
Tianyang Wu1, Dan Wang2, Taoran Liu3
1Research Center of the Ministry of Education for High Gravity Engineering and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
Bioresource technology
|January 19, 2026
概括
高重力强化臭氧化 (HiGee-O3) 通过物理和化学作用的结合,迅速使水borne抗生素耐药细菌 (ARB) 失活. 这种强效的过程为解决水生环境中抗生素耐药性的新解决方案提供了新的解决方案.
科学领域:
- 环境科学 环境科学
- 微生物学 微生物学
- 化学工程是化学工程的重要组成部分.
背景情况:
- 水中传播的抗生素耐药细菌 (ARB) 构成重大环境和公共卫生风险.
- 传统的臭氧化在禁用ARB.的效率有限.
- 增强的质量转移对于通过臭氧化的有效ARB无活化至关重要.
研究的目的:
- 调查高重力技术 (HiGee) 在增强ARB无活化臭氧化的有效性.
- 为了阐明HiGee强化臭氧化 (HiGee-O3) 的无活化机制.
- 评估工艺参数和共存物质对HiGee-O3性能的影响.
主要方法:
- 应用高重力技术 (HiGee) 来加强臭氧质量转移.
- 实施Higee-O3过程用于ARB无活化.
- 通过激素清理实验分析失活动力学和机制.
- 微观和光谱分析以确定细胞损伤.
主要成果:
- HiGee-O3在几秒钟内实现了5.3日志ARB无活化,显著优于传统方法.
- 直接的分子臭氧氧化被确定为主要的无活化机制,OH扮演次要角色.
- 观察到细胞成分,包括脂质,蛋白质,碳水化合物和核酸的氧化损伤,导致不可逆转的细胞损伤.
结论:
- 由HiGee的剪切引发的物理干扰和臭氧化学氧化的协同效应为ARB无活化提供了一个强大而有效的方法.
- HiGee-O3为缓解水环境中的抗生素耐药性提供了一个有前途的技术.
- 了解失活机制有助于优化现实世界的应用程序的过程.
相关概念视频
Development of Antibiotic Resistance
1.4K
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
1.4K
Antibiotic Selection
59.5K
Overview
59.5K
X-Inactivation
41.6K
The human X chromosome contains over ten times the number of genes as in the Y chromosome. Since males have only one X chromosome, and females have two, one might expect females to produce twice as many of the proteins, with undesirable results.
41.6K
Activation and Inactivation of G Proteins
11.2K
Heterotrimeric G proteins are guanine nucleotide-binding proteins. As the name suggests, heterotrimeric G proteins are composed of three subunits: alpha, beta, and gamma. They remain GDP-bound or GTP-bound inside the cells and switch between inactive/active states. The Gα subunit possesses the nucleotide-binding pocket that binds guanine nucleotides and switches between GDP or GTP-bound states. In contrast, the Gꞵ and Gγ subunits are always bound together with high...
11.2K
The Roles of Bacteria and Fungi in Plant Nutrition
47.0K
Plants have the impressive ability to create their own food through photosynthesis. However, plants often require assistance from organisms in the soil to acquire the nutrients they need to function correctly. Both bacteria and fungi have evolved symbiotic relationships with plants that help the species to thrive in a wide variety of environments.
47.0K
Resistivity
4.4K
When a voltage is applied to a conductor, an electrical field is generated, and charges in the conductor feel the force due to the electrical field. The current density that results depends on the electrical field and the properties of the material. In some materials, including metals at a given temperature, the current density is approximately proportional to the electrical field. In these cases, the current density can be modeled as:
4.4K


