基于移动应用程序的超记忆认知训练对轻度认知障碍的有效性和安全性:多中心随机临床试验
Sunyoung Kang1, Jung-In Lim2, Lukas Stenzel3
1Department of Psychiatry & Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
JMIR mHealth and uHealth
|January 19, 2026
概括
基于移动应用程序的超记忆训练 (MMT) 程序ET-101显著改善了轻度认知障碍 (MCI) 患者的认知功能,与假装设备相比. 这种数字治疗方法有望在MCI管理中实现更广泛的可访问性.
科学领域:
- 老年学和认知神经学.
- 数字治疗和健康技术的数字治疗和健康技术
背景情况:
- 超记忆训练 (MMT) 是一种非药理学策略,用于增强轻度认知障碍 (MCI) 的认知能力.
- 基于移动应用程序的MMT提供了更好的可访问性,但其在随机临床试验 (RCT) 环境中的有效性尚未得到充分探索.
研究的目的:
- 为了评估基于移动应用程序的MMT程序的有效性和安全性,ET-101 (Cogthera).
- 在被诊断为MCI的个体中,将ET-101与假装设备控制进行比较.
主要方法:
- 一个多中心,随机对照试验 (RCT),涉及患有MCI的参与者.
- 参与者被随机分配 (1:1) 接受12周的ET-101或假控制,并进行12周的随访.
- 认知功能,日常活动和生活质量使用阿尔茨海默病评估量表-认知子量表 (ADAS-Cog) -14作为主要结果进行评估.
主要成果:
- 在ET-101组中,在第24周保持/改善ADAS-Cog-14分数的响应者比例显著更高 (P=.002).
- ET-101组在第24周表现出显著的认知改善 (ADAS-Cog-14估计:-2.53,P=.003).
- 记忆和语言领域的改善;没有报告与干预相关的不良事件.
结论:
- 与假装设备相比,ET-101显著提高了MCI患者的认知功能.
- 观察到的记忆和语言的改善表明了转移效应,突出了ET-101的潜力.
- 移动应用平台为MCI中的MMT提供了更广泛的可访问性,克服了传统的限制.
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