相关实验视频
Updated: Jan 21, 2026

16:49
Multifocal Electroretinograms
Published on: December 4, 2011
18.8K
诊断渐进的多焦点白内障:临床特征,神经成像发现,确认测试和建议的诊断算法
Katherine M Sawicka1, Jacob Houpt2,3, Kamala Sangam3,4
1Department of Medicine, Division of Neurology, University of Toronto, Toronto, Ontario, Canada.
Practical neurology
|January 19, 2026
概括
渐进性多焦点白内障 (PML) 是由约翰·坎宁汉病毒 (JCV) 引起的严重中枢神经系统感染,需要及时诊断. 本综述通过详细介绍临床,成像和测试策略,帮助临床医生识别PML,即使在免疫能力强的个体中也是如此.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 神经病毒学 神经病毒学
背景情况:
- 渐进性多焦点白内障 (PML) 是一种严重的,机会性中枢神经系统感染.
- 它是由约翰·坎宁汉病毒 (JCV) 引起的,这是一个常见的多重瘤病毒,很少引起神经系统疾病.
- 诊断是具有挑战性的,因为各种表现,发生在免疫能力较强的个体,和不完美的诊断测试.
研究的目的:
- 审查PML的临床特征,神经成像发现和诊断方法.
- 提出一种算法,以帮助准确和及时诊断PML.
主要方法:
- 对PML的临床表现,神经成像特征和实验室诊断技术的文献综述.
- 综合信息以开发诊断算法.
主要成果:
- PML呈现出各种神经症状和特征,尽管有时是微妙的,神经成像发现.
- 对JCVDNA的脑脊液 (CSF) 分析具有不完美的灵敏度.
- 提出了一个整合临床,成像和测试数据的诊断算法.
结论:
- 准确和及时诊断PML对于患者管理至关重要.
- 拟议的算法通过整合关键诊断信息来促进诊断.
- 需要改进诊断策略,特别是对于相对免疫能力较强的主体的病例.
相关概念视频
Myocarditis II: Clinical Features and Diagnostic Tests
271
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
271
Pericarditis II: Clinical Features and Diagnostic Tests
293
Pericarditis is distinguished by inflammation of the pericardium, the fibrous sac that encases the heart. It can be acute, lasting less than six weeks, or chronic, persisting for over three months. Understanding its clinical manifestations and diagnostic findings is crucial for timely and effective management.Clinical ManifestationsWhile pericarditis can be asymptomatic, it usually presents with characteristic symptoms such as:Chest Pain: The most characteristic symptom of pericarditis is chest...
293
Mitral Stenosis II: Clinical features and Diagnostic Tests
225
Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
225
Aortic Regurgitation II: Clinical Features and Diagnostic Tests
425
Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
425
Mitral Regurgitation II: Clinical Features and Diagnostic Tests
386
Mitral regurgitation (MR) is a valvular heart disorder in which the mitral valve fails to close tightly, allowing blood to leak backward into the heart. Understanding the clinical manifestations, assessment, diagnostic findings, and medical management of MR is crucial to effectively managing affected patients.Clinical Manifestations of Mitral RegurgitationMitral regurgitation can be acute or chronic, each presenting differently and requiring different approaches:1. Acute Mitral...
386
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests
479
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
479

