分布式fMRI模式与低频心肺呼吸动态相结合,提供了衰老标志物
Shiyu Wang1, Richard Song2,3, Laurent M Lochard4
1Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37240, USA.
概括
衰老会影响大脑与身体的连接. 功能磁共振成像 (fMRI) 模式与生理信号相结合可靠地预测年龄,突出自主调节.
科学领域:
- 神经科学是一个神经科学.
- 衰老研究研究 衰老研究
- 身体生理学 身体生理学
背景情况:
- 衰老会改变大脑与身体的连接,可以通过功能磁共振成像 (fMRI) 和自主过程进行测量.
- 之前的研究指出,与年龄相关的变化,在特定的大脑区域和生理活动之间的关联.
- 大脑活动和生理信号之间的相互作用越来越被认为是重要的,超越了"噪音"的解释.
研究的目的:
- 研究与低频生理过程相关的全脑空间fMRI模式的与年龄相关的变化.
- 为了确定这些fMRI-生理学合模式是否可以预测成年人寿命中的时间年龄.
- 根据fMRI-生理学合,确定对预测年龄最有影响力的大脑区域.
主要方法:
- 分析功能磁共振成像 (fMRI) 数据从人类参与者整个成年人寿.
- 检查fMRI-生理学合的全脑空间模式,重点关注低频心率和呼吸量波动.
- 从fMRI-生理学合模式来统计预测时间年龄,控制生理信号特征和大脑解剖学.
主要成果:
- 从低频fMRI-生理学合模式来看,时间年龄在统计上是可预测的.
- 参与中央自主调节的大脑区域 (例如,胰岛,中带皮层) 是年龄的关键预测因素.
- 剩余血液氧气水平依赖 (BOLD) 信号变化,即使考虑到生理效应,仍然是一个可靠的年龄指标.
结论:
- fMRI-生理学合模式揭示了大脑与身体融合中的可概括的与年龄相关的变化.
- 这种合是衰老过程的潜在生物标志物,反映了自主功能和大脑血管健康的变化.
- 这些发现强调了大脑与身体相互作用在理解衰老和潜在的疾病相关干扰方面的重要性.
相关概念视频
00:51What is a Frequency Distribution
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A frequency is the number of times a value of the data occurs. The sum of all the frequency values represents the total number of students included in the sample. It is commonly used to group data of quantitative types. Frequency distributions can be displayed in a table, histogram, line graph, dot plot, or pie chart, just to name a few. A histogram is a graphical representation of tabulated frequencies, shown as adjacent rectangles, erected over discrete intervals (bins), with an area equal to...
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01:11Mean From a Frequency Distribution
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Sometimes, data gathered from an experiment on a large sample or population are organized into concise tables. In such cases, the frequency of the quantitative data set is plotted in the form of a table. Or else, the data values are grouped into the quantity’s intervals, which form classes, and their respective frequencies are known. That is, the data values are distributed over different categories or classes. This is known as frequency distribution.
When such a data set is encountered,...
When such a data set is encountered,...
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01:15Construction of Frequency Distribution
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A frequency distribution table can be constructed using the steps given below.
First, make a table with two columns—one with the title of the data that needs to be organized, and the other column for frequency. [Draw a third column for tally marks if needed]. Then, take a look at the items given in the data set and decide if an ungrouped frequency distribution table or a grouped frequency distribution table would be more suitable. If there are large sets of different values, then it is...
First, make a table with two columns—one with the title of the data that needs to be organized, and the other column for frequency. [Draw a third column for tally marks if needed]. Then, take a look at the items given in the data set and decide if an ungrouped frequency distribution table or a grouped frequency distribution table would be more suitable. If there are large sets of different values, then it is...
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00:57Percentage Frequency Distribution
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A percentage frequency distribution, in general, is a display of data that indicates the percentage of observations for each data point or grouping of data points. It is a commonly used method for expressing the relative frequency of survey responses and other data. The percentage frequency distributions are often displayed as bar graphs, pie charts, or tables.
The process of making a percentage frequency distribution involves the following few steps: note the total number of observations;...
The process of making a percentage frequency distribution involves the following few steps: note the total number of observations;...
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00:55Relative Frequency Distribution
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A relative frequency distribution is the proportion or fraction of times a value occurs in a data set. To find the relative frequencies, one can divide each frequency by the total number of data points in the sample. It is very similar to a regular frequency distribution, except that instead of reporting how many data values fall in a class, a relative frequency distribution reports the fraction of data values that fall in a class. These fractions or proportions are called relative frequencies...
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01:04Cumulative Frequency Distribution
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A cumulative frequency distribution is another type of frequency distribution. Instead of reporting how many data values fall in some classes, it reports how many data values are contained in either that class or any class to its left. Technically, it means the sum of frequencies of the class and all the classes below it in a frequency distribution. A cumulative frequency is calculated by adding the frequency of each class lower than the corresponding class interval or category. In general, a...
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