针对关键下重建的患者特定的可生物降解3D打印植入物的早期稳定性和降解
Hsuan-Wen Wang1, Chiao-Min Chang1, Yen Cheng2
1Department of Biomedical Engineering, National Yang Ming Chaio Tung University, Taipei, Taiwan; Medical Device Innovation & Translation Center, National Yang Ming Chiao Tung University, Taipei, Taiwan.
概括
针对患者的聚烯/β-三酸 (PCL/β-TCP) 植入物是3D打印的,用于下重建. 应力适应梯度格子设计显著提高了机械稳定性和在关键尺寸缺陷中的植入长寿.
科学领域:
- 生物材料工程 生物材料工程
- 增材制造 增材制造 增材制造
- 面外科手术 面外科手术
背景情况:
- reconstruction 在实现足够的机械支和可预测的退化方面存在挑战.
- 针对患者的植入物对于复杂解剖缺陷的最佳适合和功能至关重要.
研究的目的:
- 开发和评估使用化沉积建模 (FDM) 的30重%β-三酸 (β-TCP) 植入物增强的患者特定的可生物降解聚烯酸 (PCL) 植入物.
- 研究渐变格子结构设计对早期机械稳定性和临界大小下缺陷降解的影响.
主要方法:
- 梯度格子架构是使用基于有限元素的拓优化来设计的,孔径根据应力分布进行调整 (P06:~1000μm,P08:~1500μm).
- 两个植入器跨度 (RI-2和RI-3) 被制造和测试在机械负荷和水解降解下,以模拟早期的术后口腔条件.
主要成果:
- 该PCL/β-TCP复合物表现出良好的机械性能 (弹性模量:450 ± 20MPa) 和良好的细胞活力 (84.5%).
- RI-2的设计表现出卓越的机械稳定性,能够承受比RI-3高得多的阻力负荷和曲应力.
- 在模拟的口腔条件下,RI-2植入物在一个月内保持结构完整性,而RI-3植入物在14天内失败.
结论:
- 高含量的PCL/β-TCP复合材料适用于3D打印应力适应性下植入物.
- 梯度格子设计提供了一个可行的策略,用于优化机械支和降解配置在生物降解植入物用于面重建.
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