与代谢功能障碍相关的脂肪性肝病作为认知能力下降的危险因素:ELSA-巴西队列研究的发现
Raphael Machado Castilhos1,2, Luís Gustavo Sampaio1, Natan Feter3
1Serviço de Neurologia, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|January 19, 2026
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 并没有显示出与中年成人认知能力下降的独立联系. 进一步的研究表明,血管和代谢因素显著影响认知健康结果.
科学领域:
- 神经学 神经学
- 肝病学 肝病学是一种肝病学.
- 公共卫生 公共卫生
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 越来越多地被认为对神经健康的潜在影响.
- 以前的研究表明,MASLD与不良大脑结果之间存在联系,需要进一步调查.
研究的目的:
- 评估MASLD与纵向队列认知障碍或认知能力下降的发生率之间的关联.
- 确定MASLD是否是认知功能障碍的独立风险因素.
主要方法:
- 从长度健康成年人研究 (ELSA-巴西研究) 的数据分析.
- 在基线和随访时评估全球认知表现.
- 使用波桑回归和线性混合效应模型 (LMMs) 来测试关联的统计分析.
主要成果:
- 在基线时,MASLD在13.6%的研究参与者中被发现.
- 在MASLD和发生的认知障碍之间没有发现显著的关联 (RR: 1.01;95% CI: 0.83-1.23).
- 使用LMMs进行的纵向分析显示,MASLD与认知衰退 (p=0.2721) 之间没有独立的关联,尽管注意到了与记忆领域的基线关联.
结论:
- 在中年成年人中,MASLD与认知障碍或认知衰退没有独立的关联.
- 如MASLD所示的肝硬化症不能独立预测认知变化.
- 马斯尔德对认知的影响似乎是由潜在的血管和代谢风险因素介导的.
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