相关实验视频
Updated: May 11, 2026

20:16
Detecting Anastasis In Vivo by CaspaseTracker Biosensor
Published on: February 1, 2018
生命的基本8和整体和特定部位癌症类型的风险:一个大规模的前性队列研究
Li Deng1,2,3,4, Xiao-Meng Hao5, Zhe Shu6
1Department of Gastrointestinal Surgery, Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Cancer medicine
|January 19, 2026
概括
更高程度地遵守生命的基本8 (LE8) 显著降低了整体癌症发病率和特定癌症类型的风险. 这一框架对癌症预防策略有前途.
科学领域:
- 心血管健康和瘤学
- 公共卫生和流行病学
背景情况:
- 为预防心血管疾病而建立的生命基本8 (LE8) 框架对癌症风险有潜在的影响,尽管它与癌症发病率的直接关联需要进一步研究.
- 个别的LE8成分可能会在各种器官系统中对癌症风险产生不同的影响,需要进行详细的调查.
研究的目的:
- 调查遵守生命的基本8 (LE8) 框架和各种癌症类型的发病率之间的联系.
- 探索单个LE8组件对大型前队列癌症风险的影响.
主要方法:
- 进行了一项前性队列研究,对来自中国的Kailuan研究的94,239名参与者进行了研究.
- 使用生活方式和生物标志物数据计算LE8得分;癌症发病率追踪到2022年12月31日.
- 考克斯的比例危险和竞争风险模型被用来分析LE8坚持和癌症风险之间的关系,调整了混因素.
主要成果:
- 较高的LE8坚持与整体癌症发病率的显著降低有关,理想坚持显示26%的下降 (HR=0.74).
- LE8的改善与肺癌 (9%),乳腺癌 (12%),脏癌 (18%),结直肠癌 (7%),子宫内膜癌 (31%) 的风险降低相关.
- 理想的血压和不吸烟有保护作用,而理想的体重与风险增加有关;不吸烟特别降低了肺癌和癌风险.
结论:
- 生命的基本8 (LE8) 框架是预防癌症的一个有价值的工具,证明了更高的坚持和更低的癌症发病率之间的明显联系.
- 将LE8框架纳入公共卫生倡议和临床实践可以加强癌症预防工作.
相关概念视频
Cancer
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Cancers Originate from Somatic Mutations in a Single Cell
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
Cancer Prevention
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
Cancer Prevention
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
Cancer Vaccines
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer Survival Analysis
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...

