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Updated: Jan 21, 2026

Efficient Genome Editing of Mice by CRISPR Electroporation of Zygotes
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通过集成的计算-实验框架,设计 MmeFz2-ωRNA 系统以实现高效的基因组编辑.

Shangpu Li1,2, Kun Xu1,2, Guoling Li3,4

  • 1International Joint Agriculture Research Center for Animal Bio-Breeding of Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.

Nature communications
|January 19, 2026
PubMed
概括

改造的Fanzor蛋白在哺乳动物细胞中显示出更高的基因组编辑效率. 人工智能引导的优化带来了显著的改进,使得治疗应用,如在小鼠模型中杜氏肌肉发育不良的纠正.

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