牛乳作为一种人乳强化剂,适用于进食缓慢的非常早产婴儿:一项随机对照试验
Ping-Ping Jiang1,2, Hai-Yun Huang3, Lu Zhao4
1Department of Veterinary and Animal Sciences, University of Copenhagen, Frederiksberg, Denmark.
Pediatric research
|January 19, 2026
概括
与常规强化剂相比,用牛乳强化母乳 (BC) 对非常早产婴儿 (VPI) 是安全的,但没有改善养耐受性或临床结果. 这项研究增加了关于在VPI中使用BC的有限证据.
科学领域:
- 新生儿营养新生儿营养
- 儿科胃肠病学 儿科胃肠病学
背景情况:
- 关于为非常早产婴儿 (VPI) 用常规牛奶基增强剂的替代品增强母乳的研究有限.
- 研究诸如蛋白质丰富的牛乳粉 (BC) 等新型强化剂对于优化VPI营养至关重要.
研究的目的:
- 评估用牛乳 (BC) 强化人乳是否能改善VPI患者的食不耐受性和临床结果.
- 为了比较BC与常规强化剂 (CF) 的安全性和有效性,在VPIs中用缓慢的肠道养进步.
主要方法:
- 一个未盲目的,双中心,随机对照试验 (FortiColos CN) 涉及VPI (妊娠年龄26 0/7至31 6/7周).
- 婴儿至少两周接受了BC (n=74) 或CF (n=72) 强化的母乳,从目标肠道养量开始.
- 评估的结果包括食不耐受性,营养摄入量,生长,发病率和生化参数.
主要成果:
- 在BC和CF组之间的食不耐受,营养摄入量或身体生长参数之间没有发现显著差异 (p>0.05).
- 发病率和所有测量的血液学和生物化学参数在两组之间都相似.
- 接受BC的婴儿表现出更高水平的特定氨基酸 (Phe,Pro,Ser,Tyr,Val).
结论:
- 牛乳头 (BC) 是安全的强化母乳在非常早产婴儿 (VPIs) 接受缓慢的肠道养进步.
- 与该队列中的常规强化剂相比,BC并没有在食耐受性,生长或临床结果方面显著改善.
- 虽然BC是安全的,但根据这项研究的发现,BC对VPI的现有强化剂提供了有限的短期临床益处.
相关概念视频
Gene Evolution - Fast or Slow?
8.0K
The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
In contrast, regions which code...
8.0K
Gene Evolution - Fast or Slow?
3.4K
3.4K
Clinical Trials
10.2K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
There are four phases in a clinical trial. A phase one...
10.2K
Clinical Trials: Overview
4.6K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
4.6K
Trial and Error and Algorithm
398
A problem-solving strategy is a plan of action used to find a solution. Different strategies have distinct action plans. Trial and error involves trying different solutions until one works. For instance, to fix a broken printer, you might check ink levels, ensure the paper tray isn't jammed, and verify the printer's connection to your laptop. This method can be time-consuming but is commonly used. Thomas Edison, for example, used trial and error to find a suitable filament for the light...
398
Random Error
9.0K
Random or indeterminate errors originate from various uncontrollable variables, such as variations in environmental conditions, instrument imperfections, or the inherent variability of the phenomena being measured. Usually, these errors cannot be predicted, estimated, or characterized because their direction and magnitude often vary in magnitude and direction even during consecutive measurements. As a result, they are difficult to eliminate. However, the aggregate effect of these errors can be...
9.0K


