在早产儿的2岁生长:捐赠奶与早产婴儿配方相比
Jane E Brumbaugh1, Scott A McDonald2, Daniel T Robinson3
1Mayo Clinic College of Medicine and Science, Rochester, MN, USA. brumbaugh.jane@mayo.edu.
Pediatric research
|January 19, 2026
概括
与早产母乳养婴儿相比,早产母乳养的婴儿在出院和2岁之间体重增加较大. 这两种饮食在随访时都产生了类似的体重指数Z-分数.
科学领域:
- 新生儿营养新生儿营养
- 儿科的生长和发展.
- 临床试验研究临床试验研究
背景情况:
- 在NICHD新生儿研究网络的MILK试验中,研究了早产婴儿与早产婴儿配方奶相比,早产婴儿的生长结果.
- 根据研究饮食,提出了一个基于随访时没有生长差异的假设.
研究的目的:
- 对一项随机试验进行二次分析,比较极度早产婴儿的捐赠奶和早产婴儿配方奶.
- 为了评估生长差异,特别是身体质量指数 (BMI) Z-score,在22-26个月的校正年龄.
主要方法:
- 一项双盲试验的二次分析,该试验涉及孕期<29周或<1000克的婴儿.
- 随机分配给15个美国中心的捐赠奶或早产婴儿配方奶群.
- 主要结局:22-26个月的BMI Z-score,年龄修正.
主要成果:
- 在22-26个月的校正年龄时,包括BMI Z-score在内的人体测量在捐赠奶和配方奶群之间是相似的.
- 与配方奶组相比,在捐赠奶组 (1.04 ± 1.28) 和配方奶组 (0.73 ± 1.30) 中,从出院到随访期间,体重Z-score的显著增加.
结论:
- 虽然2年BMI Z-scores是可比的,但根据婴儿早期的饮食,出院和随访之间的生长模式有显著差异.
- 在此期间,接受捐赠奶的婴儿表现出比接受早产婴儿配方奶的婴儿更显著的体重Z-score增加.
- 捐赠奶对极度早产婴儿2年生长的早产奶粉没有劣势,这凸显了支持捐赠奶的政策的必要性.
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