通过饮食暴露于N-亚胺及其前体:年龄分层评估
Aida Zapico1,2, David Herrero-Morin3, Silvia Arboleya4,5
1Department of Functional Biology, University of Oviedo, Oviedo, 33006, Spain. zapicoaida@uniovi.es.
Scientific reports
|January 19, 2026
概括
通过饮食接触N-尼托胺 (N-NAs) 是一种癌症风险,特别是在儿童中. 加工肉类是主要来源,幼儿时期是减少摄入量和为公共卫生政策提供信息的关键时期.
科学领域:
- 食品科学与公共卫生 食品科学与公共卫生
- 毒理学和风险评估
- 营养流行病学 营养流行病学
背景情况:
- 饮食中的N-尼托胺 (N-NAs) 与所有年龄组的癌症风险增加有关.
- 儿童和老年人是特别脆弱的人群.
- 了解特定年龄的饮食摄入量和N-NA的来源对于风险管理至关重要.
研究的目的:
- 进行年龄特定的饮食摄入N-尼托胺 (N-NAs) 的风险评估.
- 为了确定N-NAs暴露的主要饮食来源.
- 评估不同年龄组的暴露率 (MOE).
主要方法:
- 利用西班牙北部116名儿童 (6个月至4岁) 和182名成年人 (19至95岁) 的671个经过验证的食物频率问卷.
- 使用EFSA和EPIC数据计算了348种食品的每100克N-NA,酸盐和酸盐含量.
- 分析了按体重标准化的摄入量,并使用FoodSources Shiny-app.com确定了饮食来源.
主要成果:
- 在48个月的儿童中,观察到最高的N-NA平均摄入量,主要是N-Nitrosodimethylamine (NDMA),主要来自加工肉类.
- 在成年人中,动物来源是酸盐摄入的主要原因,12-19%的摄入量超过了可接受的每日摄入量 (ADI).
- 在儿童中,N-NAs的最低MOE在48个月时被发现,MOE低于10,000,从12个月到95岁观察到.
结论:
- 幼儿时期是减少暴露于致癌性N-NAs的关键时间.
- 这些发现支持制定有针对性的公共卫生政策,以减轻N-NA暴露.
- 减少加工肉类的摄入量对于降低癌症风险至关重要,特别是在幼儿中.
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