深度学习分析提取的缓释吗啡中的颗粒含量:长时间沸可以减少大片段,同时保留吗啡提取
Henrik Sahlin Pettersen1,2, Per Ole M Gundersen3, Trond Oskar Aamo3
1Department of Clinical and Molecular Medicine, The Norwegian University of Science and Technology, Trondheim, NO-7491, Norway. henrik.s.pettersen@ntnu.no.
Scientific reports
|January 19, 2026
概括
注射毒品的使用者面临着从平板电脑颗粒污染的风险. 较长的沸时间 (10分钟) 显著减少颗粒,仅仅略有降低了吗啡提取效率,提供了一种减少危害的策略.
科学领域:
- 药理学和毒理学 药理学和毒理学
- 公共卫生和减少危害
- 分析化学 分析化学
背景情况:
- 注射药物使用者 (IDU) 经常从缓释口服片中提取吗啡,冒着有害颗粒污染的风险.
- 目前的注射剂使用者的提取方法可能会导致注射溶液中存在大量颗粒物.
- 了解这些方法对于制定有效的减少危害策略至关重要.
研究的目的:
- 用常见的用户方法评估从缓释片中提取吗啡的效率.
- 量化通过这些提取技术产生的过剂中的颗粒含量.
- 为减少伤害服务和医疗保健提供者提供有关风险和潜在干预措施的信息.
主要方法:
- 在60毫克的Dolcontin片上测试了四种不同的提取方法,不同的涂层去除和沸时间 (3-10分钟).
- 溶液中的吗啡含量使用液体染色学-并联质谱法 (LC-MS/MS) 来量化.
- 用幻灯片扫描和基于深度学习的图像分析 (QuPath软件) 来分析粒子内容.
主要成果:
- 在不同的方法中,吗啡回收率从81.2%到91.3%不等.
- 方法A (不去除涂层,3分钟煮沸) 产生了许多小颗粒 (<100微米).
- 方法D (去除涂层,10分钟煮沸) 在所有大小类别中产生最少的颗粒,与方法B相比,仅减少了10%的吗啡回收.
结论:
- 提取方法显著影响吗啡回收和过物的颗粒量.
- 延长沸时间 (10分钟) 在减少颗粒污染方面非常有效,吗啡的损失最小.
- 基于证据的降低危害对于减轻注射平板电脑衍生解决方案,指导咨询和服务设计的风险至关重要.
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