作为杀虫剂和人类新陈代谢调节剂的末衍生化合物
Shivanshu Garg1, Himanshu Punetha2, Saurabh Gangola3
1Department of Biochemistry, Lovely Professional University, Phagwara, 144411, Punjab, India. gshivanshu@gmail.com.
Scientific reports
|January 19, 2026
概括
烯异硫酸 (AITC) 和末油对常见的害虫具有杀虫性能. 与AITC和其他末油相比,棕末油表现出更好的昆虫威作用,这表明它有可能作为生物控制剂.
科学领域:
- 农业科学 农业科学
- 昆虫学 昆虫学是一门学科.
- 生物化学 生物化学
背景情况:
- 酸 (Allyl isothiocyanate,简称AITC) 是一种从葡萄糖酸盐水解中衍生的天然化合物,因其在人类中具有抗氧化和抗癌特性而闻名.
- 末油及其成分正在探索对农业害虫的潜在杀虫剂和抗活动.
- 了解植物化合物与昆虫和人类生物系统的相互作用,对于开发可持续的害虫管理策略至关重要.
研究的目的:
- 为了比较纯化Allyl isothiocyanate (AITC) 和三种类型的油 (黑色,棕色,白色) 对抗红甲虫 (Aulacophora foveicollis) 和烟草切虫 (Spodoptera litura) 的杀虫和抗效果.
- 研究AITC与人类抗氧化酶 (Glutathione-S-transferase和Sulfonyl transferase) 和消化酶 (pepsin) 与子蛋白 (cruciferin和napin) 的 in silico相互作用.
- 评估末衍生化合物的潜力,作为可持续农业的合成杀虫剂的环保替代品.
主要方法:
- 进行了in silico分析,以研究AITC,人类抗氧化酶和子蛋白之间的分子相互作用.
- 进行了体外生物测试,以确定AITC和末油对A. foveicollis和S. litura. 的抗和杀虫剂 (LC50值) 潜力.
- 进行了对净化AITC,棕色,黑色和白色子油的疗效进行比较分析.
主要成果:
- 纯化AITC显示出比测试的末油 (40.1878.92%) 更高的抗昆虫养潜力 (74.6388.22%).
- 棕油的LC50值最低 (602.23毫克/毫升为A. foveicollis,251.99毫克/毫升为S. litura),表明毒性高于黑和白油.
- 在体研究中发现了AITC与人类酶的关键氨基酸相互作用,以及素和子种子蛋白之间的显著结合.
结论:
- 与黑色和白色末油相比,棕末油对测试的害虫具有优越的杀虫剂和抗食活性,这可能是由于葡萄糖酸盐和脂肪酸含量更高.
- 虽然纯化的AITC显示出强大的抗养潜力,但末油,特别是棕末,在较低度下更有效地威昆虫.
- 末衍生化合物,特别是棕末油,作为经济和可持续的生物控制剂具有前景,可能取代有害的合成杀虫剂.
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