对商业CBD油的HiSorb-TD-GC-MS分析
Marios C Christodoulou1, Efstathios A Elia2, Agapios Agapiou3
1Department of Chemistry, University of Cyprus, P.O. Box 20537, 1678, Nicosia, Cyprus.
Analytical and bioanalytical chemistry
|January 19, 2026
概括
一种新的HiSorb微提取方法与热消化气体染色学质谱学 (TD-GC-MS) 相结合,可以准确地分析大麻油中的大麻素 (CBD). 这种绿色分析方法确保了可靠的CBD量化,没有THC的形成,支持产品安全和监管合规性.
科学领域:
- 分析化学 分析化学
- 绿色化学 绿色化学
- 药物鉴定学是指药物鉴定学.
背景情况:
- 准确量化大麻产品中的大麻二醇 (CBD) 对消费者安全和监管合规至关重要.
- 现有的分析方法可能缺乏效率,敏感性或环境可持续性.
- 需要开发快速,可靠和环保的分析技术,用于大麻衍生产品.
研究的目的:
- 开发和验证一种新的HiSorb微提取方法,用于分析商业大麻油中的CBD.
- 为了评估不同的HiSorb吸收涂层的性能,以获得最佳的CBD提取.
- 评估开发的常规分析方法的绿色性和适用性.
主要方法:
- 使用三相 (PDMS/CWR/DVB) 和双相 (PDMS/CWR) 吸附涂层进行HiSorb微提取.
- 提取优化使用水浴化在80°C2小时.
- 分析与热吸附气体染色学和质谱学 (TD-GC-MS) 相结合.
主要成果:
- 三相HiSorb涂层显示出优异的CBD回收.
- 开发的TD-GC-MS方法表现出极好的线性 (R2=0.9951),低的LOD (30μg/mL) 和LOQ (100μg/mL).
- 高精度 (RSD < 7.7%),令人满意的恢复 (77.2-86.4%) 和没有 Δ9-THC 的形成.
- 绿色评估得分是同意=0.75和同意准备=0.54.
- 对商业大麻油的分析显示,标签声明和测量CBD度之间没有显著的统计差异.
结论:
- 开发的HiSorb-TD-GC-MS方法是一种敏感,精确和高效的技术,用于大麻油中的CBD量化.
- 该方法是绿色的,在分析过程中不会诱导CBD对THC的异构化.
- 这种经过验证的方法可以可靠地应用,以确保商业大麻油产品的质量和安全.
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