含有化合物的水果提取物对Streptococcus mutans的生存能力的影响:一个体外研究
Karin Zornitzki1, Daniel Z Bar1, Avital Shmerling1
1Department of Pediatric Dentistry, The Maurice and Gabriela Goldschleger School of Dental Medicine, Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.
概括
石榴皮提取物有效地抑制了Streptococcus mutans (S. mutans) 的生长,这种细菌是导致的关键细菌. 这种天然提取物显示出与赫西丁相似的疗效,这表明口腔健康应用的潜力.
科学领域:
- 口腔微生物学 口腔微生物学
- 自然产品化学 自然产品化学
- 抗微生物剂是一种抗菌剂.
背景情况:
- 突变性菌株 (S. mutans) 是口腔微生物群中的一种主要的菌性细菌.
- 牙损仍然是一个重大的全球健康问题.
- 需要用于口腔健康的新型抗菌剂.
研究的目的:
- 评估各种水果提取物对S. mutans生长的剂量反应关系.
- 确定果实提取物抑制S. mutans.的最小有效度.
- 为了比较水果提取物与标准抗菌剂的疗效.
主要方法:
- 制备水果提取物 (蔓越,桃,葡萄,石榴皮,石榴汁) 并连续稀释.
- 对S. mutans生长的抑制作用在1,5和20μg/μl度下在6小时内被评估.
- 无菌脱离离子水和0.2%的化分别作为负和正对照.
主要成果:
- 所有测试的水果提取物都显示出一种剂量依赖的抑制S. mutans生长.
- 葡萄,蔓越和桃提取物在5和20μg/μl时观察到显著的抑制.
- 石榴皮提取物 (20μg/μl) 显示出最强的抑制作用,相当于0.2%的素.
结论:
- 石榴皮提取物是S. mutans在体外的一个强有力的抑制剂.
- 石榴皮提取物在20μg/μl时的疗效与赫西丁相匹配.
- 石榴皮提取物作为口腔健康应用中的天然替代品具有前景.
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