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在双胞胎怀孕中,超声波和基于SNP的无细胞DNA双胞胎性测试

Ruben Quintero¹, K Joseph Hurt², Neeta L Vora³

¹Department of Fetal Therapy, The Fetal Institute, Coral Gables, FL, USA.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

|January 19, 2026

概括

在超声波中添加基于SNP的无细胞DNA (cfDNA) 结合性测试,可以改善双胞胎怀孕中的胆管性评估. 这有助于识别双胞胎双胞胎 (DZ),可能有助于改善临床管理和理解分娩结果.

科学领域:

孕产妇和胎儿医学孕产妇和胎儿医学
遗传学是一个遗传学.
产科产科产科产科产科

背景情况:

在双胞胎怀孕的管理中,产前确定胆管性至关重要.
有限的研究存在于产前性测试对双胞胎怀孕管理的贡献.

研究的目的:

评估基于SNP的无细胞DNA (cfDNA) 结合超声波对双胞胎怀孕中胆管状性评估的结合性测试的有用性.
评估结合性对临床管理和分娩结果的影响.

主要方法:

一项涉及13个美国实践的前性观察研究.
第一个三个月的双胞胎怀孕,通过超声波评估胆管性和cfDNA对形性.
胎盘病理被用作表性确认的黄金标准.

主要成果:

cfDNA的密度测试有助于正确地分类胆性,解决超声波的差异.
在分娩时的中位妊娠年龄在单胞胎 (MZ) 双胞胎 (35.0周) 和双胞胎 (DZ) 双胞胎 (36.9周) 之间较早.
与DZDC双胞胎相比,MZ双胞胎,特别是MZ二 (DC) 双胞胎的出生体重和百分位数明显较低.

结论:

在双胞胎怀孕中,cfDNA结合性测试补充了超声波在产前胆管结合性分配中的作用.
双胞胎怀孕的双胞胎性测试可以提高双胞胎怀孕的管理.
需要进行更大规模的研究来证实对双胞胎怀孕管理中的结合性测试的临床价值.

关键词:

他们是双胞胎,双胞胎.胆性胆性胆性非侵入性的产前检测.产前诊断在产前诊断.这就是Zygosity.

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