动脉硬和抑郁与老年中国人口中新发自报告的慢性阻塞性肺病的联合关联
Qinqin Shen1, Xingyun Zhu2, Yu-Jun Xiong3
1Department of Respiratory and Critical Care Medicine, Beijing Jishuitan Hospital, Capital Medical University, Xicheng District, Beijing, People's Republic of China.
动脉硬和抑郁独立地增加患慢性阻塞性肺病 (COPD) 的风险. 虽然这两种因素都有所贡献,但它们的综合效应是显著的,尽管调解效应很小.
科学领域:
- 心血管健康 心血管健康
- 肺部医学 肺部医学
- 心理健康 心理健康
背景情况:
- 慢性阻塞性肺病 (COPD) 是一个重大的全球健康挑战.
- 动脉硬和抑郁症对COPD发病率的联合影响尚未得到充分理解.
研究的目的:
- 研究动脉硬和抑郁对新发性COPD发展的独立和联合影响.
- 探索动脉硬和抑郁在COPD发作中的潜在调解作用.
主要方法:
- 一项队列研究利用了来自中国健康和退休长度研究 (2011-2018) 的数据,涉及45岁及以上的成年人.
- 考克斯的比例危险模型和调解分析被用来评估估计的脉冲波速度 (ePWV),抑郁症状 (CESD-10) 和发生的COPD之间的关联.
主要成果:
- 在7年的时间里,718名参与者患上了COPD.
- 升高的ePWV (HR=1.11) 和抑郁症 (HR=1.63) 都独立地与COPD风险增加有关.
- 伴随性病例呈现最高风险 (HR=2.17),在两个方向上观察到统计学上显著但很小的调解效应.
结论:
- 增加的动脉硬和抑郁症状独立地与发生的COPD有关.
- 虽然从统计学上显著,但观察到ePWV和COPD发展中的抑郁症之间的调解效应是小的和探索性的.
- 建议通过客观测量和因果设计进行进一步的研究,以证实这些产生假设的发现.
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