在牙周健康和疾病中,唾液 Galectin-8, Galectin-9 和 RANKL 水平的比较分析
Kübra Aydın Er1, Huriye Erbak Yılmaz2,3, Figen Narin2
1Department of Periodontology, Faculty of Dentistry, Izmir Katip Celebi University, Izmir, Turkey.
Oral diseases
|January 20, 2026
概括
唾液 galectin-8, galectin-9 和 RANKL 在牙周病中升高. 加勒-9显示为牙炎和牙周炎的诊断生物标志物最有前途.
科学领域:
- 牙周病学 牙周病学
- 生物标志物发现发现
- 口腔健康研究研究 口腔健康研究
背景情况:
- 牙周病,包括牙周炎和牙周炎,是全球健康的重大负担.
- 目前的诊断方法依赖于临床参数,需要探索新的生物标志物.
- 唾液生物标志物为早期检测和监测牙周状况提供了一种非侵入性的方法.
研究的目的:
- 在健康的牙周,牙周炎和牙周炎的个体中,比较唾液中的 galectin-8, galectin-9 和核因子Kappa-B连接体 (RANKL) 受体激活剂水平.
- 评估这些唾液生物标志物的诊断潜力,以区分牙周病的不同阶段.
主要方法:
- 一项涉及60名全身健康,非吸烟参与者的横截面研究,分为健康,牙炎和牙周炎组 (每组n=20).
- 对所有参与者来说,临床牙周参数都被仔细记录下来.
- 使用酶相关免疫吸收试验 (ELISA) 量化了加列-8,加列-9和RANKL的唾液度.
主要成果:
- 与健康组相比,在牙炎和牙周炎组中都观察到明显升高的胆素-8,胆素-9和RANKL的唾液水平 (p <0.05).
- 与牙周炎组相比,牙周炎组中这些生物标志物的水平也明显高于牙周炎组 (p < 0.05).
- 接受器操作特征 (ROC) 分析表明,在区分牙周病方面,加勒-9表现出最高的诊断准确性 (AUC = 0.946),超过了加勒-8 (AUC = 0.832) 和RANKL (AUC = 0.780).
结论:
- Salivary galectin-8, galectin-9和RANKL在牙周病存在时升高,这表明它们作为诊断生物标志物的潜在用途.
- 与galectin-8和RANKL相比,galectin-9在识别牙周病方面表现出更好的区分能力.
- 这些发现强调了加勒-9作为一种有前途的唾液生物标志物,用于非侵入性诊断牙周疾病.
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