诱导可塑性皮肤周围神经刺激治疗部疼痛:一个盲目的随机临床试验
Francisco J Ortega1, Maria José Giner2,3, Laura Pérez-Cervera2
1Department of Physiotherapy, CEU-Cardenal Herrera University, Elche, Spain.
European journal of pain (London, England)
|January 20, 2026
概括
皮肤周围神经刺激 (pPNS) 有效地减少了部疼痛,感觉值突破高频刺激 (ST-bHFS) 显著减少了自发疼痛. 这种非药理学方法在临床疼痛管理方面表现有前途.
科学领域:
- 神经科学是一个神经科学.
- 疼痛管理 疼痛管理
- 神经调节是一种神经调节.
背景情况:
- 之前的动物研究表明,通过皮肤周围神经刺激 (pPNS) 协议诱导突触可塑性,从而导致缺痛症.
- 这些pPNS协议在人类临床群体内缓解疼痛的有效性仍未得到研究.
- 这项研究的重点是非特异性部疼痛患者.
研究的目的:
- 研究pPNS协议对非特异性部疼痛患者疼痛症状的影响.
- 为了比较传感门爆发高频刺激 (ST-bHFS) 和运动门甲爆发刺激 (MT-TBS) 与主动对照 (TENS) 的疗效.
主要方法:
- 45名参与者被随机分为三个组:ST-bHFS,MT-TBS或80 Hz TENS (主动控制).
- 用口头数值评分尺度 (VRNS) 评估自发性和运动诱导的疼痛.
- 在治疗前和治疗后评估了上梯形的最大强度和电肌图.
主要成果:
- ST-bHFS显著降低了自发部疼痛 (p < 0.001),这种效果在MT-TBS或TENS中没有发现.
- 所有方案都减少了运动引起的疼痛,尽管只有MT-TBS和ST-bHFS获得了临床相关性.
- 在pPNS两组 (MT-TBS和ST-bHFS) 中,疼痛减轻持续治疗后一周,与TENS组不同.
结论:
- pPNS协议,特别是ST-bHFS,为非特异性部疼痛提供了有效的非药物治疗.
- 观察到的疼痛减轻,特别是自发性疼痛,以及其持久性强调pPNS作为一个有前途的治疗选择.
- 这些发现支持将塑性诱导的pPNS协议转化为临床实践,用于疼痛管理和未来的研究.
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