在儿科Shigella sonnei中出现的Ceftriaxone耐药性:一项10年的回顾性研究
Antoni Skripai1,2, Aviv Katz1,2, Jonathan Lellouche3,4
1Department of Pediatrics, Laniado Hospital, Netanya, Israel.
Acta paediatrica (Oslo, Norway : 1992)
|January 20, 2026
概括
自2022年以来,以色列儿科患者中抗塞夫特里亚克森的Shigella sonnei菌株迅速增加. 抗菌素耐药性增加需要更新治疗指南和加强对Shigella sonnei感染的监测.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 抗菌素耐药性 (AMR) 是一个日益增长的全球健康威胁.
- 儿童感染Shigella sonnei很常见,这对公共卫生构成了重大挑战.
- 对于诸如 ceftriaxone 等关键抗生素的新兴耐药性使治疗选择复杂化.
研究的目的:
- 评估Shigella sonnei.的抗微生物耐药性模式的时间趋势.
- 专门调查抗塞夫特里亚克森抗性Shigella sonnei菌株的出现和流行情况.
- 为了分析与儿科患者中 ceftriaxone 耐药性相关的临床特征.
主要方法:
- 通过便培养诊断的儿科Shigella sonnei病例的10年回顾性研究.
- 对临床数据,实验室结果和住院时间的审查.
- 分析 ceftriaxone 耐药性的趋势,并比较耐药和敏感的分离物.
主要成果:
- 分析了180例儿科Shigella sonnei病例;11.9%的分离物是抗的.
- 观察到 ceftriaxone 耐药性的显著增加,特别是从 2022 年起 (p < 0.001).
- 耐药病例与较低的中性粒细胞和水平有关.
结论:
- 自2022年以来,抗塞夫特里亚克森的Shigella sonnei在以色列儿童群体中迅速出现.
- 这一趋势反映了全球抗菌素耐药性模式的增加.
- 迫切需要加强抗菌素耐药性监测,并更新儿童甲状病毒感染的经验治疗指南.
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