局部晚期黑色素瘤的外科手术前利祖马布:现实世界单中心回顾性研究
Simon Goller1, Tassilo Dege1, Patrick Schummer1
1Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, Germany.
Acta dermato-venereologica
|January 20, 2026
概括
晚期黑色素瘤的外科 pembrolizumab 显示可行性和有希望的疗效. 在现实环境中分析了病理反应率和生存结果,这表明有潜力指导治疗策略.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 黑色素瘤研究 黑色素瘤研究
背景情况:
- 与晚期可切除黑色素瘤相比,使用 pembrolizumab 的外科手术免疫检查点抑制 (ICI) 显示出优异的病理反应和无事件生存率 (EFS),与辅助ICI相比.
- 关于术后ICI治疗黑色素瘤的疗效和安全性的现实数据有限.
研究的目的:
- 为了评估外科手术期间 pembrolizumab 在可切除IIIBIV阶段黑色素瘤的患者的实际有效性和安全性.
- 评估病理反应率,早期生存结果和与治疗相关的不良事件.
主要方法:
- 对20名可切除黑色素瘤患者进行了回顾性单中心研究,这些患者接受了外科手术期间的pembrolizumab治疗.
- 分析放射和病理反应,无事件生存率 (EFS),无复发生存率,总生存率和黑色素瘤特异性生存率.
- 随访时间中位数为13.9个月.
主要成果:
- 20名患者中有18名接受了手术,其中44%的患者实现了病理完整反应.
- 一年EFS为66.5%,无复发生存率为77.6%,整体生存率为89.2%.
- 免疫相关的不良事件发生在50%的患者中,15%的患者经历了等级≥3的事件.
结论:
- 术后 pembrolizumab 是可行的,并在现实世界黑色素瘤队列中显示出有希望的疗效和耐受性.
- 病理反应评估可以为手术和辅助治疗决定提供信息.
- 需要进一步的研究,以优化黑色素瘤的外科手术期间ICI策略.
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