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Updated: Jan 21, 2026

Methylnitrosourea MNU-induced Retinal Degeneration and Regeneration in the Zebrafish: Histological and Functional Characteristics
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RP1L1 (R45W) 的过度活跃的微管结合是视网膜退化的基础,并被糖醇抑制

Yuqi Ye1, Zhengyang Guo1, Wei Li2

  • 1Tsinghua-Peking Center for Life Sciences, Beijing Frontier Research Center for Biological Structure, McGovern Institute for Brain Research, State Key Laboratory of Membrane Biology, School of Life Sciences and MOE Key Laboratory for Protein Science, Tsinghua University, Beijing, China.

Journal of cell science
|January 20, 2026
PubMed
概括

蛋白质RP1L1的突变导致有毒的功能增加,导致光受体中的微管结合增加. 甘油可以逆转这种效应,为遗传性视网膜疾病提供潜在的治疗策略.

关键词:
微管的动力学 微管的动力学RP1L1 的意思是小分子调制 蛋白质-微管体相互作用

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