手握强度预测主观认知衰退的认知衰退:2年随访结果
Eun Ye Lim1, Yun Jeong Hong2, Jee Hyang Jeong3
1Department of Neurology, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Journal of Korean medical science
|January 20, 2026
概括
主观认知能力下降的老年人手握力 (HGS) 降低与粉样蛋白病理和认知能力下降有关,特别是在视觉空间和执行功能方面.
科学领域:
- 神经学 神经学
- 老年学是一门学科.
- 生物标志物 生物标志物
背景情况:
- 手握强度 (HGS) 是认知能力下降的潜在标志物.
- 它与特定的认知领域和粉样蛋白病理学的关系需要进一步澄清.
研究的目的:
- 研究HGS与主观认知衰退 (SCD) 的老年人特异性认知变化之间的关联.
- 探索粉样蛋白病理学在这种关系中的作用.
主要方法:
- 在24个月内对107名患有SCD的老年人进行了纵向研究.
- 基于手握强度 (HGS) 弱点的分类,使用亚洲 Sarcopenia 工作组的标准.
- 后勤回归和重复测量ANOVA分析认知变化和HGS关联,调整共变量和粉样蛋白阳性.
主要成果:
- 患有HGS弱点的个体显示出更高的粉样质正子发射断层扫描 (PET) 阳性 (47.1%与18.9%对比).
- HGS的弱点与较差的基线以及视觉空间和执行功能的下降相关.
- HGS的弱点预测视觉空间功能和口头记忆的下降,尽管调整为粉样蛋白阳性后的意义下降了.
结论:
- 在患有SCD的老年人中,HGS的弱点与视觉空间和执行领域的认知衰退有关.
- 它可能表明早期的粉样蛋白相关的神经退行.
- HGS评估是识别有风险个体的实用工具,特别是在没有粉样蛋白PET的情况下.
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