清细胞细胞癌中的代谢重编程:核心途径和向治疗策略
MingWei Zhan1, BinBin Zhao1,2, Haote Chen1
1Department of Urology, Hangzhou TCM Hospital of Zhejiang Chinese Medical University (Hangzhou Hospital of Traditional Chinese Medicine), Hangzhou, China.
Frontiers in genetics
|January 20, 2026
概括
清细胞细胞癌 (ccRCC) 呈现出显著的代谢变化,包括改变碳代谢和脂质积累,影响预后和治疗. 针对这些代谢脆弱性,以及免疫反应,为ccRCC提供了新的精确瘤学策略.
科学领域:
- 在瘤学瘤学.
- 代谢途径 代谢途径
- 癌症免疫学 癌症免疫学
背景情况:
- 清细胞细胞癌 (ccRCC) 的特点是VHL损失,导致失调的缺氧诱导因子 (HIF) 信号传递.
- 这导致了深刻的代谢重编程,包括增强的葡萄糖分解,改变的TCA循环,脂质积累,依赖谷氨和单碳代谢.
- 这些代谢转变与免疫抑制瘤微环境密切相关.
研究的目的:
- 绘制关键代谢途径 (碳,脂质,氨基酸,单碳) 和它们与ccRCC中的铁化相互作用的地图.
- 阐明代谢异质性和代谢-免疫交叉在ccRCC预后和治疗耐药性的作用.
- 概述ccRCC治疗中的精密代谢瘤学的转化策略和决策框架.
主要方法:
- 整合单细胞和空间多基因组学,代谢和脂质组学分析以及成像数据.
- 分析代谢途径节点,碳流,脂质代谢,以及它们与铁亡的联系.
- 关于代谢-免疫合及其对免疫治疗耐药性的影响的综合证据.
主要成果:
- 代谢异质性,以DCCD频谱为例,显著影响ccRCC的预后和治疗反应.
- 代谢-免疫合,包括免疫细胞中的脂质重新连接和代谢压力,有助于抵抗免疫疗法.
- 新兴的诊断工具,如放射病理学和循环代谢指纹,对伴随诊断有很大的希望.
结论:
- 针对代谢途径 (HIF-2α,脂质代谢用于铁,谷氨酸,单碳) 与现有疗法 (ICI,TKI) 结合,具有治疗前景.
- 基于DCCD状态,脂质表型,铁灭敏感性和HIF活动的分层决策框架可以指导个性化的ccRCC治疗.
- 数据原则的标准化和生物标志物丰富的试验对于在ccRCC中推进精确代谢瘤学至关重要.
关键词:
DCCDD是DCCD,是DCCD的发行商,是DCCD的发行商.贝尔祖蒂芬是个很好的球员.清细胞细胞癌 (ccRCC) 是一种癌症.铁性化 (ferroptosis) 是一种谷氨胺的代谢过程免疫代谢的免疫代谢.脂质滴滴/PLIN2 在线一个碳代谢的一个碳代谢.更多相关视频
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