序列C-反应蛋白作为治疗反应和急性手部感染疾病严重性的敏感标记
Sunandan Datta1, Bratati Bandyopadhyay1, Lydia S Abraham2
1Trauma and Orthopaedics, Aneurin Bevan University Health Board, Newport, GBR.
Cureus
|January 20, 2026
概括
在急性手部感染中,C-反应蛋白 (CRP) 水平比白细胞 (WBC) 计数更有效地追踪治疗反应. 串行CRP监测有助于管理感染和优化医院资源.
科学领域:
- 传染性疾病 传染性疾病
- 手术感染 手术感染
- 生物标记分析 生物标记分析
背景情况:
- 急性手部感染是手术入院的常见原因,导致患者患病率显著.
- 反应蛋白 (CRP) 和白细胞 (WBC) 计数是感染的标准生物标志物,但它们在监测治疗反应中的有用性尚未明确.
研究的目的:
- 为了比较串行C反应蛋白 (CRP) 测量与白细胞 (WBC) 计数在监测急性手部感染治疗反应中的疗效.
- 调查入院CRP水平,感染严重程度和患者结果之间的相关性.
主要方法:
- 进行了对69名具有培养阳性急性手部感染患者的回顾性队列研究.
- 人口,临床,微生物学数据以及串行CRP和WBC水平被收集和分析.
- CRP和WBC的趋势与感染类型和临床反应相关.
主要成果:
- 虽然89.86%的患者在入院时CRP升高,但只有23.2%的患者患有白细胞病.
- 平均CRP水平从入院到出院显著下降 (72.4毫克/升至18.6毫克/升;p<0.001),与非显著的WBC变化不同 (p=0.184).
- 与表面感染相比,在深部手部感染中观察到更高的摄入CRP水平 (112.3 mg/L与38.7 mg/L; p=0.002).
结论:
- 连续CRP测量是治疗反应的更敏感的指标,比WBC数量在急性手感染.
- 升高的入院CRP水平与更深层次的感染和长时间住院有关.
- 将连续CRP监测集成到临床实践中,可以提高抗生素管理,排放规划和资源分配.
相关概念视频
Parkinson's Disease: Treatment
1.0K
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
1.0K
Alzheimer's Disease: Treatment
832
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
832
The Unfolded Protein Response
6.3K
The ER is the hub of protein synthesis in a cell. It has robust systems to quality control protein folding and also for degradation of terminally misfolded proteins. Under normal conditions, a small proportion of misfolded proteins that cannot be salvaged need to be transported to the cytoplasm by the ER-associated degradation or ERAD pathways. However, if the ERAD cannot handle the misfolded proteins, the cell activates the unfolded protein response or UPR to adjust the protein folding...
6.3K
Serial Position Effect
524
The serial position effect is a cognitive phenomenon where individuals are more likely to recall the first and last items in a list compared to those in the middle. This effect is divided into the primacy effect and the recency effect. The primacy effect is observed when the initial items in a list are remembered better. This occurs because these items are rehearsed more frequently or receive more elaborative processing, allowing them to be encoded into long-term memory more effectively. For...
524
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
443
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
443
Regulation of the Unfolded Protein Response
2.9K
Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...
2.9K


