患有多发性硬化症的患者治疗ocrelizumab的严重晚发性中性
Mohamed K Mansour1, Raju Raghunathan2, Ali Mohamed3
1Internal Medicine, Rochester Regional Health, Rochester, USA.
Cureus
|January 20, 2026
概括
奥克雷利祖马布有效治疗多发性硬化症,但可能导致晚发性中性 (LON). 使用抗生素和G-CSF的早期干预对于在MS患者中管理这种严重的副作用至关重要.
科学领域:
- 免疫学 免疫学 免疫学
- 神经学 神经学
- 血液学 血液学 血液学
背景情况:
- 奥克雷利祖马布是一种针对CD20的单克隆抗体,用于多发性硬化症 (MS).
- 虽然有效,但ocrelizumab可能会导致不良事件,包括晚发性中性 (LON).
研究的目的:
- 在患有复发性缓解性多发性硬化症 (RRMS) 的患者接受奥克雷利祖马布治疗后报告严重中性缺血病例.
- 强调对ocrelizumab诱导的LON的监测和及时干预的重要性.
主要方法:
- 一个36岁的女性RRMS患者的病例报告.
- 记录了临床表现,实验室发现 (绝对中性粒细胞计数 - ANC) 和治疗干预措施.
主要成果:
- 患者在服用奥克雷利祖马布后出现严重的中性缺血症 (ANC 0.11 × 109/L).
- 用宽谱抗生素和花细胞殖民地刺激因子 (G-CSF) 治疗导致显著的临床改善.
结论:
- 晚期发病的中性质是与ocrelizumab治疗相关的重大临床挑战.
- 警地监测血细胞计数和及时的G-CSF治疗对于管理MS患者的ocrelizumab诱导的中性质是必不可少的.
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