角膜弧与心血管疾病的关系:系统性审查
Haidar Bonajmah1, Faisal Aljassar2, Ali Bulbanat3
1Department of Ophthalmology, Kuwait Institute for Medical Specialization, Kuwait City, KWT.
Cureus
|January 20, 2026
概括
角膜弧 (arcus senilis) 与心血管疾病 (CVD) 风险因素和疾病流行有关. 虽然它可以预测年轻男性的事件,但其预后价值在老年人中有限.
科学领域:
- 眼科医生 眼科 眼科
- 心脏病学 心脏病学
- 流行病学 流行病学
背景情况:
- 角膜弧 (arcus senilis) 对心血管疾病 (CVD) 的预后意义尚未完全确定.
- 角膜弧是角膜周围的脂质环,通常与衰老和脂质失调有关.
研究的目的:
- 系统地审查观察性研究,评估角膜弧与心脏代谢风险,流行心血管疾病和发生的心血管事件之间的关联.
- 在检查角膜弧和心血管疾病的研究中评估风险因素调整的一致性.
主要方法:
- 对观察性研究 (1960-2017年) 的系统审查,包括横截面,病例控制和前性队列设计.
- 使用纽卡斯尔-太华尺度和乔安娜·布里格斯研究所检查清单进行偏见风险评估.
- 包括来自亚洲,欧洲和北美的12项研究.
主要成果:
- 角膜弧的患病率随着年龄的增长而增加,在男性中更高.
- 在横截面和病例控制研究中发现了弧形,动脉质脂质配置和流行心血管疾病之间的一致关联.
- 展望数据显示,Arcus在年轻男性和一些亚洲男性人群中预测了事件事件,但在一般,老年人群中具有有限的独立预后价值.
结论:
- 角膜弧主要反映了累积的脂质暴露.
- 在50岁以下的成年人或选择高风险男性中,弧的存在需要进行脂质评估和风险评估.
- 由于角膜弧的缺失,并不能排除心血管疾病,因为它的敏感性较低.
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