弥合差距:在巴基斯坦的低资源环境中,使用自动化HyperARC用于脑转移的线性加速器 (LINAC) 放射外科手术的第一个临床经验.
Aqueel Shahid1, Tabinda Sadaf2, Asma Rashid2
1Radiation Oncology, McGill University, Montreal, CAN.
Cureus
|January 20, 2026
概括
HyperArc体积调制弧线疗法 (HA-VMAT) 为大脑转移提供了精确的治疗. 这项研究表明,HA-VMAT在立体射线手术/放射治疗中是安全有效的,改善了局部控制并减少了并发症.
科学领域:
- 辐射瘤学 辐射瘤学
- 神经外科 神经外科
- 医学物理 医学物理
背景情况:
- 大脑转移是癌症治疗中日益关注的问题.
- 立体射线手术 (SRS) 和分离立体射线疗法 (fSRT) 是有限的大脑转移的标准治疗方法.
- 像基于线性加速器 (LINAC) 的HyperArc体积调制弧线疗法 (HA-VMAT) 这样的先进系统提供了高精度的放射治疗.
研究的目的:
- 报告最初的临床经验,使用大脑转移的HA-VMAT规划方法.
- 评估HA-VMAT在治疗大脑转移中的安全性和有效性.
主要方法:
- 使用HA-VMAT使用SRS/SRT治疗的72名脑转移1-5例患者的回顾性分析.
- 临床特征和患者结果的剂量测量评估.
- 治疗涉及单分数SRS或分数SRT,使用不同的处方剂量 (EQD2).
主要成果:
- 在2020年4月至2021年6月期间,72名患者的86例脑转移被治疗.
- 乳腺癌是最常见的组织学 (66.7%).
- 在12.5%的患者中观察到完全反应,无进展生存期为1年,54.6%. 仅发生了一例辐射死亡病例.
结论:
- HA-VMAT是一种安全有效的技术,用于用SRS/fSRT治疗大脑转移.
- 这种方法增强了当地控制,并最大限度地降低了局部并发症的风险.
- 临床结果表明HA-VMAT在脑转移管理中的可行性.
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