丰坦相关肝细胞癌:病例报告和管理困境
Bushra Mohandes1, Salama Almheiri2, Hajer Saleh Busharar2
1General Surgery, Mohamed bin Rashid University of Medicine and Health Sciences, Dubai Health, Dubai, ARE.
Cureus
|January 20, 2026
概括
丰坦相关性肝病 (FALD) 增加了肝细胞癌 (HCC) 的风险,即使没有肝硬化. 对于Fontan手术幸存者来说,早期意识和监测至关重要.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 在瘤学瘤学.
背景情况:
- 丰坦相关性肝病 (FALD) 是丰坦手术后的一种已知的并发症.
- 升高的中央静脉压 (CVP) 会导致肝细胞水平的肝损伤.
- 肝细胞癌 (HCC) 可以在FALD患者中发展,无论肝硬化.
- 芬坦患者患上HCC的风险较高,即使没有肝硬化变化.
研究的目的:
- 为了突出Fontan相关性肝病 (FALD) 患者肝细胞癌 (HCC) 的风险.
- 在没有肝硬化的情况下,在年轻的成年人Fontan后手术中呈现HCC病例.
- 强调需要提高医生意识和对这一群体的监测.
主要方法:
- 一个24岁的男性患有低可塑性左心综合征和威尔布兰德病的病例报告,Fontan手术后16年.
- 临床表现包括右上象限腹部疼痛和发烧.
- 通过CT扫描的诊断成像显示了多焦点肝病变.
- 放射性特征与HCC一致,没有证据表明肝硬化.
主要成果:
- 患者出现了暗示肝脏病理的症状.
- CT扫描证实了多焦点肝病变,具有HCC的成像特征.
- 没有观察到肝硬化组织学或放射学证据.
- 这个案例说明了在没有肝硬化的Fontan患者中HCC的发展.
结论:
- 芬坦相关性肝病 (FALD) 患者患肝细胞癌 (HCC) 的风险增加,即使没有肝硬化.
- 管理Fontan幸存者的医生需要对这种风险有更高的认识.
- 建议实施结构化监测计划,以便在这种高风险队列中早期检测HCC.
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