周血管脂肪组织与血管壁重塑之间的关系:系统性审查和元分析
Anna Bragina1,2, Yulia Rodionova1,2, Konstantin Osadchiy1
1Department of Faculty Therapy No. 2, I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.
Vascular medicine (London, England)
|January 20, 2026
概括
宫外脂肪,特别是周血管脂肪组织 (PVAT),与血管硬和重塑有关. 早期发现功能障碍PVAT对于评估所有个体的心血管风险至关重要.
科学领域:
- 心血管科学 心血管科学
- 代谢健康 代谢健康
- 血管生物学 血管生物学
背景情况:
- 宫外脂肪和血管硬之间的关系尚未得到充分理解.
- 缺乏围血管脂肪组织 (PVAT) 和血管重塑指数的系统审查.
研究的目的:
- 系统地审查和分析PVAT与血管壁重塑和动脉硬的标志物之间的关联.
- 调查诸如脉冲波速率 (PWV),增强指数 (AI),心脚血管指数 (CAVI),内皮依赖血管扩张 (EDV) 和内膜介质厚度 (IMT) 等指数.
主要方法:
- 一个系统的文献审查,遵循PRISMA指南.
- 在PubMed,Scopus和Web of Science数据库中进行的搜索.
- 来自8项涉及1244名参与者的研究数据的元分析,使用随机效应模型.
主要成果:
- 在胸腔周心脏脂肪组织密度和cfPWV/AI (r=0.56) 之间发现了显著的相关性.
- 冠状动脉外介质厚度 (EMT) 与大动脉PWV相关 (r=0.56).
- 胸腔周动脉脂肪体积与CAVI相关 (r=0.49).
结论:
- PVAT与血管壁重塑有关.
- 功能障碍的PVAT可能会导致心血管风险增加.
- 早期发现PVAT功能障碍对于健康个体和心血管疾病患者的风险评估至关重要.
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