相关实验视频

Updated: Jan 21, 2026

Use of MRI-ultrasound Fusion to Achieve Targeted Prostate Biopsy

Use of MRI-ultrasound Fusion to Achieve Targeted Prostate Biopsy

Published on: April 9, 2019

超声波介导的向微/纳米气泡:突破精确瘤治疗的新界限

Miao Yang¹, Zhenyu Zhang¹, Hongxiu Zhou²

¹State Key Laboratory of High-performance Precision Manufacturing, Cancer Hospital of Dalian University of Technology, Liaoning Cancer Hospital & Institute, Dalian University of Technology, Dalian, China.

International journal of surgery (London, England)

|January 20, 2026

概括

超声中介的向微/纳米气泡 (UMT-MNBs) 提供了一种新的,非侵入性的癌症治疗方法. 这种方法增强了药物输送,克服了耐药性,并激活了免疫反应,以改善恶性瘤治疗.

科学领域:

生物医学工程生物医学工程
在瘤学瘤学.
纳米技术纳米技术

背景情况:

恶性瘤带来了重大的公共卫生挑战,其发病率和死亡率不断上升.
传统的癌症治疗缺乏特异性,导致严重的副作用.
目前的免疫疗法面临的局限性包括瘤透率低,向效率低,免疫逃避等.

研究的目的:

审查针对恶性瘤治疗的超声中介向微/纳米气泡 (UMT-MNBs) 的最新进展.
突出UMT-MNBs作为一个非侵入性,高度向的,克服治疗挑战的非病毒载体.
探索UMT-MNBs与精准医学常规疗法的协同作用潜力.

主要方法:

关于UMT-MNBs在药物/基因输送,缺氧调节,抗性减轻和免疫激活方面的最新文献的综述.
在包括化疗,放射治疗和光疗在内的组合疗法中分析UMT-MNBs.
对UMT-MNBs进行血液-脑屏障透的讨论.

主要成果:

UMT-MNBs促进向药物释放,克服药物耐药性,并激活免疫系统.
这种方法增强了免疫细胞的过,抑制了瘤血管生成,并诱导了免疫细胞死亡.
UMT-MNBs与传统疗法具有协同作用,减少剂量和毒性.

结论:

UMT-MNBs代表了对恶性瘤的有前途的治疗策略,推动了精准医学的发展.
未来的研究应该专注于优化超声波参数,MNB表面功能化和免疫机制阐明.
在癌症治疗中,UMT-MNB为向治疗,免疫治疗和组合策略提供了新的方向.

关键词:

UMTMNBs 已经成为一个国家.癌症治疗治疗治疗癌症综合疗法综合疗法没有侵入性的非侵入性.目标定位目标定位目标定位

更多相关视频

A Brain Tumor/Organotypic Slice Co-culture System for Studying Tumor Microenvironment and Targeted Drug Therapies

A Brain Tumor/Organotypic Slice Co-culture System for Studying Tumor Microenvironment and Targeted Drug Therapies

Published on: November 7, 2015

Introduction to the Ultrasound Targeted Microbubble Destruction Technique

Introduction to the Ultrasound Targeted Microbubble Destruction Technique

Published on: June 12, 2011

相关概念视频

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

Fixing Double-strand Breaks

Fixing Double-strand Breaks

The double-stranded structure of DNA has two major advantages. First, it serves as a safe repository of genetic information where one strand serves as the back-up in case the other strand is damaged. Second, the double-helical structure can be wrapped around proteins called histones to form nucleosomes, which can then be tightly wound to form chromosomes. This way, DNA chains up to 2 inches long can be contained within microscopic structures in a cell. A double-stranded break not only damages...

Fixing Double-strand Breaks

Fixing Double-strand Breaks

Areas Within Irregular Boundaries

Areas Within Irregular Boundaries

Calculating areas within irregular boundaries, such as along rivers or curved roads, is crucial in various fields, including surveying, engineering, and environmental management. Surveyors often begin by creating a traverse, a connected series of straight lines approximating the area's boundary. The coordinates of each traverse point are essential for calculating the enclosed area. The double meridian distance formula is a widely used technique for this purpose. This method utilizes the...

Electrostatic Boundary Conditions

Electrostatic Boundary Conditions

Consider an external electric field propagating through a homogeneous medium. When the electric field crosses the surface boundary of the medium, it undergoes a discontinuity. The electric field can be resolved into normal and tangential components. The amount by which the field changes at any boundary is given by the difference between the field components above and below the surface boundary.
The surface integral of an electric field is given by Gauss's law in integral form and is related to...

Magnetostatic Boundary Conditions

Magnetostatic Boundary Conditions

An electric field suffers a discontinuity at a surface charge. Similarly, a magnetic field is discontinuous at a surface current. The perpendicular component of a magnetic field is continuous across the interface of two magnetic mediums. In contrast, its parallel component, perpendicular to the current, is discontinuous by the amount equal to the product of the vacuum permeability and the surface current. Like the scalar potential in electrostatics, the vector potential is also continuous...