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Updated: Jan 22, 2026

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一个折叠开关调节了阿尔法病毒RNA依赖RNA聚合酶的构造

Jamie J Arnold1,2, Sean M Braet3, Luiz C Vieira4

  • 1Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, United States.

Nucleic acids research
|January 20, 2026
PubMed
概括

奥尼翁-尼翁病毒nsP4 (RNA-依赖RNA聚合酶) 采用一个不活跃的扩展形状,在蛋白质分解裂变时切换到一个活跃的紧形状. 这种机制可以防止在细胞质中发生不必要的病毒RNA合成.

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