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Updated: Jan 22, 2026

Ileectomy-induced Bile Overaccumulation in Mouse Intestine
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使用PBPK建模评估肠道胆汁盐对药物吸收的影响:对efavirenz,cinnarizine和posaconazole的案例研究

Laura G Al-Amiry Santos1, Sebastian Polak1,2, Karen Rowland Yeo1

  • 1Certara UK Limited, Sheffield, UK.

CPT: pharmacometrics & systems pharmacology
|January 20, 2026
PubMed
概括

胆汁盐对于吸收难溶药物至关重要,尤其是在禁食时. 了解它们的度是准确的药物吸收建模的关键.

关键词:
在 PBPK 建模中使用 PBPK 模型.吸收药物吸收药物吸收肠道胆汁盐 肠道胆汁盐药物动力学 药物动力学灵敏度分析是一种灵敏度分析.

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