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Updated: Jan 22, 2026

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在基于模型的元分析中结合综合数据和个人患者数据:对托法西提尼布在类风湿关节炎患者中的说明性案例研究

Thao-Nguyen Pham1,2, Anna Largajolli2, Maria Luisa Sardu2

  • 1Normandie Univ, UNICAEN, CNRS, ISTCT, GIP CYCERON, Caen, France.

CPT: pharmacometrics & systems pharmacology
|January 20, 2026
PubMed
概括

个人患者数据 (IPD) 在没有共变量的基于模型的元分析 (MBMA) 中提供了有限的好处. 然而,分层IPD显著提高了MBMA中的共变模型性能,改善了治疗效应的检测.

关键词:
汇总数据 汇总数据 汇总数据个体患者数据 个体患者数据基于模型的元分析.

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