德尔-1是一种内源性衰老蛋白,可以抑制衰老相关的骨质损失
Jong-Hyung Lim1, Kridtapat Sirisereephap2,3, Hui Wang1,4
1Department of Basic and Translational Sciences, Laboratory of Innate Immunity and Inflammation, Penn Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
发育性内皮位-1 (DEL-1) 是一种内源蛋白质,可以清除衰老的骨髓介质细胞 (BM-MSCs). 这一发现提供了一种潜在的治疗策略,用于对抗与年龄相关的骨退化和牙周炎.
科学领域:
- 老年学是一门学科.
- 细胞生物学 细胞生物学
- 生物化学 生化学
背景情况:
- 衰老细胞,包括骨髓中酶体 stromal 细胞 (BM-MSCs),在骨微环境中积累,导致与年龄相关的骨退化.
- 发育内皮位-1 (DEL-1) 的表达,一种分泌的蛋白质,随着年龄的增长而下降.
研究的目的:
- 研究DEL-1作为一种内源性老化蛋白在清除老化的BM-MSCs中的作用.
- 探索DEL-1在预防老化相关的骨损失和其他与年龄相关的疾病中的治疗潜力.
主要方法:
- 研究了DEL-1通路涉及β3整合素/CD73/腺素/p38 MAPK/BCL-2在衰老的BM-MSC亡中.
- 使用了缺少DEL-1的小鼠和具有内皮特异性的DEL-1过度表达 (EC-Del1) 的小鼠.
- 服用DEL-1或DEL-1诱导的大化物,以评估对衰老标志物和骨质损失的影响.
主要成果:
- DEL-1通过特定的分子途径促进衰老的BM-MSCs的亡,从而导致它们被巨细胞清除.
- 缺少DEL-1会加剧骨质损失,而过度表达DEL-1会减少骨质损失.
- 服用DEL-1可降低衰老标志物,并逆转与衰老相关的牙周炎.
结论:
- 德尔-1作为一种内源性老化蛋白质,能够清除老化的BM-MSCs.
- 德尔-1具有作为治疗剂的潜力,可以预防衰老细胞的积累,治疗与年龄相关的骨损失和牙周炎.
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