牙周炎的辅助疗法:当前的概念和未来
Rafael Scaf de Molon1, Joao Paulo Steffens2, Erica Dorigatti de Avila1
1Department of Diagnostic and Surgery, School of Dentistry, São Paulo State University (UNESP), São Paulo, Brazil.
Journal of periodontal research
|January 20, 2026
概括
翻译牙周炎辅助疗法的临床前发现需要改进的模型和标准化的结果. 专业调解剂,益生菌和人工智能驱动的工具等创新可以增强临床整合和患者的结果.
科学领域:
- 牙周医学 牙周医学
- 翻译研究是翻译研究.
- 治疗创新 治疗创新
背景情况:
- 牙周炎涉及慢性炎症和骨损失,需要超出机械生物膜控制的辅助疗法.
- 将临床前发现转化为有效的牙周炎临床治疗仍然是一个重大挑战.
- 目前的研究强调了需要改进的翻译方法和创新的辅助策略.
研究的目的:
- 批判性地审查牙周炎管理中的翻译研究方法和辅助治疗创新.
- 检查如何更有效地将临床前发现连接到临床实践.
- 确定有前途的辅助模式和新兴的翻译工具.
主要方法:
- 叙事综述综合了实验,转化和临床研究的证据,截至2025年9月.
- 强调机械洞察力,模型有效性和各种附加的翻译可行性.
- 分析当前动物模型的局限性及其对人类推断的影响.
主要成果:
- 动物模型提供了机械的见解,但有局限性 (物种间的差异,动力学,终点) 影响翻译可预测性.
- 有前途的辅助疗法包括专门的亲解决媒介,益生菌,天然化合物 (黄素,白醇) 和抗菌光动力学疗法.
- 新兴的工具,如生物响应传递系统,纳米载体,3D支架和人工智能驱动的精密牙周学,显示出潜力.
结论:
- 协调的翻译模型,生物响应传递平台和精确诊断对于推进辅助牙周治疗至关重要.
- 将方法论的严谨性与治疗创新的结合,可以加速新疗法的临床整合.
- 改进的翻译研究是将临床前疗效与牙周炎管理的现实结果相结合的关键.
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