通过导电-压电集成微结构导管逐步调节细胞氧化应激,以增强神经再生
Dong Zhou1, Mengxuan Bian2, Lingyu Wei1
1The State Key Laboratory of Bioreactor Engineering and Key Laboratory for Ultrafine Materials of Ministry of Education, Materials Science and Engineering, East China University of Science and Technology, Shanghai, 200237, China.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|January 20, 2026
概括
这项研究引入了一种新的复合神经管道,该管道结合了物理指导,氧化应激减缓和电刺激,以显著提高大鼠的外周神经修复和运动功能恢复.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 神经科学是一个神经科学.
背景情况:
- 由于复杂的神经结构和微观环境,外围神经损伤 (PNI) 给自我修复带来了重大挑战.
- 人造神经管对于弥合神经间隙和促进再生至关重要.
- 现有的导管往往缺乏多模式功能,以充分支持神经愈合.
研究的目的:
- 设计和评估一种用于增强外围神经修复的新型导电-零电集成微结构导管.
- 研究物理指导,减少氧化石墨烯 (rGO) 和超声波激活电刺激对神经再生的协同效应.
- 评估管道在促进细胞迁移,减少氧化应激和改善运动功能恢复方面的有效性.
主要方法:
- 使用聚乳糖醇酸 (PLGA) 和聚乙烯化物 (PVDF) 通过电制造一个压电纳米纤维膜的制造.
- 用减少的石墨烯氧化物/甲基化凝 (rGO/GelMA) 凝复合物增强膜.
- 在体外评估微管表面的细胞迁移.
- 使用老鼠坐骨神经损伤模型进行体内评估,包括评估低强度脉冲超声波 (LIPUS) 刺激后氧化应激和运动功能的恢复.
主要成果:
- 管道的微面图案在体外有效地引导了定向细胞迁移.
- 减少的石墨烯氧化物 (rGO) 显著调节了细胞氧化应激,在体内有助于神经修复.
- 在小鼠坐骨神经损伤模型中,低强度脉冲超声波 (LIPUS) 诱导的电刺激增强了运动功能的恢复.
- 该rGO/GelMA@PVGA复合管道展示了协同效益,整合了物理线索,抗氧化特性和电刺激.
结论:
- 开发的rGO/GelMA@PVGA复合管道为外围神经修复提供了一个有前途的多式模式策略.
- 管道的集成功能提供物理指导,抑制氧化应激,并利用超声波激活的电刺激.
- 这种方法在推进外围神经损伤的临床治疗方面具有显著的潜力.
相关概念视频
Responses to Heat and Cold Stress
14.7K
Every organism has an optimum temperature range within which healthy growth and physiological functioning can occur. At the ends of this range, there will be a minimum and maximum temperature that interrupt biological processes.
14.7K
GTPases and their Regulation
9.8K
Guanine nucleotide-binding proteins (G-proteins), also known as GTPases, are a superfamily of proteins that regulate many cellular processes, such as cell signaling, vesicular transport, and the regulation of cell shape and motility. Mutation or dysfunction of these proteins can lead to disease. There are around 40,000 known G-proteins that can broadly be classified into two groups ‒ small G-proteins consisting of a single domain and large multi-domain G-proteins.
Large G-proteins,...
Large G-proteins,...
9.8K
Master Transcription Regulators
7.7K
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
7.7K
Epigenetic Regulation
33.5K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.5K
Oxidation Numbers
42.2K
In redox reactions, the transfer of electrons occurs between reacting species. Electron transfer is described by a hypothetical number called the oxidation number (or oxidation state). It represents the effective charge of an atom or element, which is assigned using a set of rules.
42.2K
Regulated Protein Degradation
8.8K
It is vital to regulate the activity of enzymatic as well as non-enzymatic proteins inside the cell. This can be achieved either through creating a balance between their rate of synthesis and degradation or regulating the intrinsic activity of the protein. Both these regulation mechanisms play an essential role in the normal functioning of cells.
Protein degradation plays two important roles in the cells. It helps to protect cells from misfolded or damaged proteins before they lead to a...
Protein degradation plays two important roles in the cells. It helps to protect cells from misfolded or damaged proteins before they lead to a...
8.8K


