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Updated: Jan 22, 2026

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埃法维伦兹和CYP2C9遗传多态性减少了健康参与者的CYP2C9活性

Jason D Kim1, Ingrid F Metzger1,2, Jessica Bo Li Lu1

  • 1Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Clinical and translational science
|January 20, 2026
PubMed
概括

长期使用埃法维伦兹会抑制细胞染色体P450 2C9 (CYP2C9) 的活体活性,从而增加托尔布塔米德水平. 这种药物相互作用需要对患者进行监测和剂量调整 efavirenz 和 CYP2C9 基质.

关键词:
在CYP2C9的活性方面.抗逆转录病毒药物 抗逆转录病毒药物细胞染色体P450的使用.药物 药物相互作用基因型-DDI影响在活体中抑制抑制.

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