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在亨廷顿病中捕捉行为症状使用亨廷顿病行为问卷.

Siena Rigatuso1, Krisha Bagga1, Shelby Hughes1,2

  • 1Department of Neurosciences, University of California, San Diego, San Diego, California, USA.

Movement disorders clinical practice
|January 20, 2026
PubMed
概括

亨廷顿病行为问卷 (HD-BQ) 有效捕捉亨廷顿病 (HD) 的行为症状. 伴侣报告显示的症状比患者的自我报告更严重,突出显示了HD患者的无意识症.

关键词:
亨廷顿病就是亨廷顿病.没有任何的异常.行为症状 行为症状双线告密者评估是如何进行的?

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Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show...
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