在发育中的大脑中由尼可类药物诱导的神经毒性:系统性审查
Dhanshree Sayangrushi Borkar1, Dnyaneshwari Shivshankar Pande1, Rajesh Singh Yadav1
1School of Forensic Science, National Forensic Sciences University (An Institution of National Importance), Ministry of Home Affairs, Government of India, Bhopal, India.
概括
类杀虫剂可以损害人类和动物发育中的神经系统. 这份对35项研究的综述证实,新烟类药物暴露会导致神经毒性影响和行为变化,需要进一步调查.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 神经科学是一个神经科学.
背景情况:
- 环境污染物对健康构成重大风险,特别是发育神经毒性.
- 作为广泛使用的杀虫剂,尼可类药物越来越多地受到对非标生物的潜在不良影响的审查.
- 虽然它们的设计是针对昆虫的尼古丁乙胆受体 (nAChRs),但对于它们对哺乳动物神经系统的影响存在担忧.
研究的目的:
- 系统地审查和全面概述与尼可类药物暴露相关的发育神经毒性.
- 综合从临床和实验研究中关于尼可类药物诱导的神经毒性的发现.
- 识别当前研究中的差距,并突出未来研究的领域.
主要方法:
- 在PubMed,ScienceDirect和Semantic Scholar数据库中进行了系统的文献搜索.
- 通过使用与新类类药物和发育性神经毒性相关的选定关键词来确定研究.
- 应用了PRISMA指南进行研究选择,结果包括了35项相关的临床和实验研究.
主要成果:
- 对所选研究的分析表明,新烟类药物暴露与各种神经毒性变化有关.
- 在动物模型中,在暴露于尼可类药物后,始终观察到行为异常.
- 有证据表明神经系统中可能存在神经病理学,生化和遗传变化.
结论:
- 尼可类药物暴露对人类和动物产生发育神经毒性的风险.
- 进一步的研究是有必要的,以充分理解神经健康的新烟类药物暴露的机制和长期后果.
- 调查神经病理,神经,生化和遗传变化对于风险评估至关重要.
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