Limosilactobacillus mucosae 通过肠口轴减轻过脂性牙周炎的作用
Jing Xu1, Ziyi Han1, Qing Xue1
1Department of Orthodontics, Hospital of Stomatology, Jilin University, Changchun, Jilin, People's Republic of China.
Gut microbes
|January 20, 2026
概括
一个肠口腔轴连接高胆固醇和牙疾病. 恢复肠道Limosilactobacillus粘膜或其代谢物甘氨酸胆 (α-GPC) 通过加强上皮屏障来保护牙.
科学领域:
- 微生物学 微生物学
- 牙周病学 牙周病学
- 代谢综合征是代谢综合征的一种.
背景情况:
- 超脂血症和牙周炎之间的联系是已知的,但机制尚不清楚.
- 一个肠口腔轴被建议调解这种联系.
- 肠道疾病与代谢疾病和炎症有关.
研究的目的:
- 研究肠道微生物群在超脂性牙周炎 (HPD) 中的作用.
- 为了确定涉及肠口轴的特定微生物和代谢因素.
- 探索针对肠口轴的HPD治疗策略.
主要方法:
- 对人体样本和小鼠模型的多omics分析.
- 便微生物群移植以确定因果关系.
- 通过口服服用Limosilactobacillus mucosae和葡萄糖胆 (α-GPC) 的药物.
- 评估牙周炎症和骨质平衡.
主要成果:
- 肠道L. 粘膜减少是HPD的一个标志.
- 通过移植L. mucosae,可以通过恢复α-GPC来改善HPD.
- 单独服用α-GPC补充剂可以通过上调Claudin-1 (CLDN1) 来保护牙周组织.
- 增强上皮屏障可以减少炎症并保护骨.
结论:
- 在肠口腔轴中确定了一个保护性L. mucosae-α-GPC-CLDN1轴.
- 肠道微生物群在代谢相关的牙周炎中调解炎症.
- 这个轴为HPD提供了潜在的治疗目标.
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