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Updated: Jan 22, 2026

Isolation of Proximal Fluids to Investigate the Tumor Microenvironment of Pancreatic Adenocarcinoma
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KRASG12R-突变胰腺癌具有有限的ERK/MAPK转录活动和独特的瘤微环境

Rachel A Burge1, Ozgun Le Roux2, Olesja Popow3

  • 1Medical University of South Carolina Charleston, SC United States.

Cancer research
|January 20, 2026
PubMed
概括

在胰腺癌中KRASG12R突变显示瘤生长速度较慢,比KRASG12D更好的生存率. 这是由于ERK/MAPK信号减少和不同的瘤微环境,这表明KRASG12R作为预后生物标志物.

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