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在Roux-en-Y或一次解剖胃旁路术后的第一年,身体组成和休息能量消耗的变化
Jari E Karppinen1, Sini Heinonen1,2, Tuure Saarinen3
1Obesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
American journal of physiology. Endocrinology and metabolism
|January 20, 2026
概括
减肥手术后的减肥减少了由于质量损失和适应性热生成而导致的休息能量消耗 (REE). 在早期,自适应性热生成占REE下降的44%,但这种影响在12个月后还不清楚.
科学领域:
- 代谢和内分泌学
- 腹部外科手术的结果
- 身体组成分析 身体成分分析
背景情况:
- 在减肥期间,休息能量消耗 (REE) 减少.
- 器官-组织质量损失和适应性热生成对REE下降的相对贡献在腹部外科手术后还不清楚.
- 比较Roux-en-Y胃绕道 (RYGB) 和一个解肠胃绕道 (OAGB) 对于理解外科手术结果很重要.
研究的目的:
- 量化REE下降的组成部分在减肥手术后的第一年.
- 为了比较RYGB和OAGB对身体组成和REE的影响.
- 确定适应性热生成在早期术后REE变化中的作用.
主要方法:
- 双能X射线吸收度 (DXA) 和MRI衍生的方程被用于评估肥胖的42名成年人的身体组成和器官组织质量.
- 间接热量计测量了基线29名参与者的REE,手术后6个月和12个月.
- 追踪了体重减轻和身体组成的变化,并分析了REE下降的质量减轻和适应性热生成的贡献.
主要成果:
- 参与者体重显著减轻 (21%在6个月,25%在12个月),RYGB和OAGB之间没有差异.
- 在6个月后,REE减少了383 kcal/d,适应性热生成占~168 kcal/d (44%).
- 12个月后,REE仍然较低,但自适应性热生成没有统计学意义;这两种程序都显示了相似的身体组成和REE变化.
结论:
- 适应性热生成在减肥手术后的REE早期下降方面有显著的贡献,与器官组织质量损失一起.
- 这种热能效应在手术后12个月减少.
- 在身体成分变化和REE减少方面,RYGB和OAGB产生了可比的结果.
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