老年人非霍奇金淋巴瘤的全球负担:使用GBD 2021的一项基于人口的研究
Yue Wang1, Jie Chen1, Jindou Guo2
1Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing, 100142, China.
Annals of hematology
|January 20, 2026
概括
非霍奇金淋巴瘤 (NHL) 在全球范围内对老年人群产生重大影响. 虽然发病率正在上升,但死亡率正在下降,预计到2035年,发病率稳定,死亡率迅速降低.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 老年病的医生 老年病的医生
背景情况:
- 非霍奇金淋巴瘤 (NHL) 对老年人群构成越来越大的健康挑战.
- 有限的精确数据存在于NHL的全球负担,特别是在这个人口群体.
研究的目的:
- 使用2021年全球疾病负担数据,对65岁及以上个体的NHL全球负担进行划分.
- 分析年龄,周期和出生队列对老年人NHL疾病负担的影响.
主要方法:
- 利用了2021年全球疾病负担研究数据.
- 描述了65岁以上个人NHL的全球流行,发病率和死亡率.
- 估计年龄,周期和出生队列对NHL负担的影响.
主要成果:
- 在2021年,超过110万个NHL流行病例记录在65岁以上的个人中,年龄标准化流行率为每10万人中148.21.
- 新增病例为306,296例,死亡人数为158,813,年龄标准化发病率和死亡率分别为每10万人中59.20和21.46.
- 从1990年到2021年,发病率和患病率有所增加,而死亡率和残疾调整后寿命年数则下降. 死亡风险随着年龄的增长而增加,但在2004年后有所改善,并且在晚期出生队伍中显示出较低的风险.
结论:
- 在老年男性中,NHL的负担更高,并且在地理位置上有所不同.
- 高社会人口统计指数国家的发病率和死亡率较高,而低社会人口统计指数国家的发病率较低但死亡率较高.
- 预计发病率将保持稳定,而死亡率预计到2035年将大幅下降,需要针对老年男性进行有针对性的干预,以及针对特定地区的临床改善.
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