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Updated: Jan 22, 2026

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阿尔法-防御素通过RNF31信号传递促进巨细胞的炎症激活

Jungnam Lee1, Naweed Mohammad1, Seyoung Mun2,3

  • 1Division of Pulmonary, Critical Care and Sleep Medicine, University of Florida, Gainesville, FL, USA.

Genes & genomics
|January 20, 2026
PubMed
概括

阿尔法防御素 (α-defensins) 通过通过RNF31和NF-κB信号来激活巨细胞来放大呼吸道炎症. 这种巨细胞激活驱动了与上皮细胞的通信,恶化了肺损伤,并突出了RNF31作为治疗点.

关键词:
阿尔法-defensins 的防御支气管上皮细胞是支气管上皮细胞.细胞因子 (cytokines) 是一种细胞因子.巨细胞是一个巨细胞.在 NF-κB p65 中.中性粒细胞中性粒细胞.在RNF31中使用.

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