Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Fibril-associated Collagen01:11

Fibril-associated Collagen

3.2K
Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
3.2K
Reaction Mechanisms03:06

Reaction Mechanisms

30.5K
Chemical reactions often occur in a stepwise fashion, involving two or more distinct reactions taking place in a sequence. A balanced equation indicates the reacting species and the product species, but it reveals no details about how the reaction occurs at the molecular level. The reaction mechanism (or reaction path) provides details regarding the precise, step-by-step process by which a reaction occurs.
For instance, the decomposition of ozone appears to follow a mechanism with two steps:
30.5K
Collagens are the Major Structural Proteins of ECM01:13

Collagens are the Major Structural Proteins of ECM

5.6K
Three main types of fibers are secreted by fibroblasts: collagen fibers, elastic fibers, and reticular fibers. Collagen fiber is made from fibrous protein subunits linked together to form a long, straight fiber. Collagen fibers, while flexible, have great tensile strength, resist stretching, and give ligaments and tendons their characteristic resilience and strength. These fibers hold connective tissues together, even during the body's movement.
Connective tissue proper includes loose...
5.6K
Mechanical Protein Functions01:58

Mechanical Protein Functions

5.5K
Proteins perform many mechanical functions in a cell. These proteins can be classified into two general categories- proteins that generate mechanical forces and proteins that are subjected to mechanical forces. Proteins providing mechanical support to the structure of the cell, such as keratin, are subjected to mechanical force, whereas proteins involved in cell movement and transport of molecules across cell membranes, such as an ion pump, are examples of generating mechanical force. 
5.5K
Type IV Collagen of Basal Lamina01:05

Type IV Collagen of Basal Lamina

3.0K
Type IV collagen is a 400 nm long, network-forming collagen that acts as a barrier between the epithelial and endothelial cells. Type IV collagen  forms the backbone of the basement membrane by scaffolding with laminin, entactin, proteoglycans, and fibronectin. Apart from rendering structural support to the basement membrane, it also helps entail signaling potentials necessary for both pathological and physiological functions.
A type IV collagen molecule has six alpha chains which can...
3.0K
Mechanism of Conjugation01:19

Mechanism of Conjugation

875
Bacterial conjugation is a mechanism of horizontal gene transfer that enables the exchange of genetic material between bacterial cells through direct contact. This process is facilitated by a donor cell carrying a conjugative plasmid, which encodes genes necessary for pilus formation, DNA replication, and transfer. The conjugative plasmid plays a central role in initiating and executing the transfer of genetic material.The tra region of the conjugative plasmid encodes proteins responsible for...
875

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Integrating Multiscale FE2M Simulations and Experiments to Predict Microcrack Damage in Cartilage.

Journal of biomechanical engineering·2026
Same author

Tension in the ranks: Cooperative cell contractions drive force-dependent collagen assembly in human fibroblast culture.

Matter·2025
Same author

On the mechanics of networked type II collagen: Experiments, constitutive modeling, and validation.

Acta biomaterialia·2025
Same author

Soluble allogeneic telocollagen as a direct protein therapeutic: results of serial injections in a rodent rotator cuff tear model.

Journal of shoulder and elbow surgery·2024
Same author

Traumatic brain injury and the pathways to cerebral tau accumulation.

Frontiers in neurology·2023
Same author

Mechanochemistry of collagen.

Acta biomaterialia·2023
Same journal

Future Directions in Biotechnological and Pharmacological Applications of CAIs.

Sub-cellular biochemistry·2026
Same journal

Industrial and Environmental Applications of Carbonic Anhydrases.

Sub-cellular biochemistry·2026
Same journal

Applications of Carbonic Anhydrase Inhibitors in Arthritis, Neuropathic Pain, Acute Mountain Sickness, and Cerebral Ischemia.

Sub-cellular biochemistry·2026
Same journal

Applications of Carbonic Anhydrase Inhibitors in Neurological Disorders, Mechanisms and Therapeutic Potential.

Sub-cellular biochemistry·2026
Same journal

Carbonic Anhydrase Inhibitors in Oncology.

Sub-cellular biochemistry·2026
Same journal

Therapeutic Applications of Carbonic Anhydrase Inhibitors in Ophthalmology.

Sub-cellular biochemistry·2026
查看所有相关文章

相关实验视频

Updated: Jan 22, 2026

A Method to Study the Correlation Between Local Collagen Structure and Mechanical Properties of Atherosclerotic Plaque Fibrous Tissue
13:45

A Method to Study the Correlation Between Local Collagen Structure and Mechanical Properties of Atherosclerotic Plaque Fibrous Tissue

Published on: November 11, 2022

2.5K

原机械学 原机械学

Phoebe Szarek1, Jeffrey W Ruberti2

  • 1Department of Bioengineering, Northeastern University, Boston, MA, USA.

Sub-cellular biochemistry
|January 20, 2026
PubMed
概括
此摘要是机器生成的。

原蛋白是脊椎动物的关键蛋白质,形成了一个多功能结构系统. 它的三环螺旋图案和等级组织使结缔组织中的各种机械功能能够发挥作用,突出显示了它的进化重要性.

关键词:
原蛋白是一种原蛋白.连接组织连接组织.纤维是一种纤维.纤维素是纤维的组成部分.机械学 机械学 机械学

更多相关视频

Planar Gradient Diffusion System to Investigate Chemotaxis in a 3D Collagen Matrix
09:26

Planar Gradient Diffusion System to Investigate Chemotaxis in a 3D Collagen Matrix

Published on: June 12, 2015

8.9K
Production of Nanofibrillar Patterned Collagen for Tissue Engineering
07:34

Production of Nanofibrillar Patterned Collagen for Tissue Engineering

Published on: September 20, 2024

942

相关实验视频

Last Updated: Jan 22, 2026

A Method to Study the Correlation Between Local Collagen Structure and Mechanical Properties of Atherosclerotic Plaque Fibrous Tissue
13:45

A Method to Study the Correlation Between Local Collagen Structure and Mechanical Properties of Atherosclerotic Plaque Fibrous Tissue

Published on: November 11, 2022

2.5K
Planar Gradient Diffusion System to Investigate Chemotaxis in a 3D Collagen Matrix
09:26

Planar Gradient Diffusion System to Investigate Chemotaxis in a 3D Collagen Matrix

Published on: June 12, 2015

8.9K
Production of Nanofibrillar Patterned Collagen for Tissue Engineering
07:34

Production of Nanofibrillar Patterned Collagen for Tissue Engineering

Published on: September 20, 2024

942

科学领域:

  • 生物化学 生物化学
  • 结构生物学 结构生物学
  • 生物材料科学 生物材料科学

背景情况:

  • 原蛋白超级家族包括所有脊椎动物中发现的至少28种蛋白质,这些蛋白质对于连接组织的支持至关重要.
  • 纤维原蛋白 (I-III,V,XI,XIV,XVII类型) 构成一个多样化的结构聚合物系统.
  • 了解原蛋白的作用对于理解组织机制和功能至关重要.

研究的目的:

  • 审查单个原蛋白分子的化学,结构和机制.
  • 探索从分子到组织层面的原体的整合.
  • 为了检查先进的主题,如交叉链接和机械化学在原.

主要方法:

  • 文献综述侧重于原蛋白结构功能关系.
  • 从分子到组织的层次一体化分析.
  • 检查诸如纤维直径调制和交叉连接等现象.

主要成果:

  • 三重螺旋形图案是原蛋白的有效和多功能结构构建块.
  • 原蛋白的层次组织 (分子,纤维,纤维,组织) 决定了机械性质.
  • 连接组织表现出了显著的多功能性,所有这些都依赖于原蛋白来实现机械功能.

结论:

  • 原蛋白的结构和等级组合是连接组织机制的基础.
  • 原蛋白的多功能性使其能够在不同的组织中发挥不同的机械作用.
  • 需要对原体机械化学和相关现象进行进一步的研究.